نتایج جستجو برای: active site pattern
تعداد نتایج: 1079201 فیلتر نتایج به سال:
Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...
HCV-induced hepatitis is one of the most debilitating diseases. The limited number of anti-HCV drugs and drug-resistance necessitate developing of new scaffolds with different mode of actions. HCV non-structural protein 5B (NS5B) is an attractive target for development of novel inhibitors of HCV replication. In this paper, new N'-arylidene-6-(benzyloxy)-4-oxo-1,4-dihydroquinoline-3-carbohydrazi...
MOTIVATION TFBS is a set of integrated, object-oriented Perl modules for transcription factor binding site detection and analysis. It implements objects representing specificity profile matrices, binding sites and sets thereof, pattern generators, and pattern database interfaces. The modules are interoperable with the BioPerl open source system. AVAILABILITY AND SUPPLEMENTARY INFORMATION The ...
Due to huge, unstructured and scattered amount of data available on web, it is very tough for users to get relevant information in less time. To achieve this, improvement in design of web site, personalization of contents, prefetching and caching activities are done according to user's behavior analysis. User's activities can be captured into a special file called log file. There are ...
The four members of the MEF2 family of MADS-box transcription factors, MEF2-A, MEF2-B, MEF2-C and MEF2-D, are expressed in overlapping patterns in developing muscle and neural cell lineages during embryogenesis. However, during late fetal development and postnatally, MEF2 transcripts are also expressed in a wide range of cell types. Because MEF2 expression is controlled by translational and pos...
Multi site modeling of rainfall is one of the most important issues in environmental sciences especially in watershed management. For this purpose, different statistical models have been developed which involve spatial approaches in simulation and modeling of daily rainfall values. The hidden Markov is one of the multi-site daily rainfall models which in addition to simulation of daily rainfall...
Three-dimensional models of thrombin complexed with large fragments of the fibrinogen Aalpha and Bbeta chains are presented. The models are consistent with the results of recent mutagenesis studies of thrombin and with the information available on naturally occurring fibrinogen mutants. Thrombin recognizes fibrinogen with an extended binding surface, key elements of which are Tyr(76) in exosite...
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