The purpose of this article is to synthesize some novel 1,8-Naphthyridine-3-Carboxylic acid derivatives, analyze them, and assess their antibacterial potential. With the help elemental analysis, IR, NMR, mass spectrum data, synthesized derivatives were identified. Derivatives' activity was determined using cup plate diffusion method. At doses 50 μg/ml 100 μg/ml, substance demonstrated substanti...

Objective: The purpose of the research was to implement molecular docking simulation investigate anti-inflammatory capability against thioesterase-2, an essential component inflammatory reaction in humans. Methods: After obtaining three-dimensional structures arthritis ligand and thioesterase-2 protein from IUPHAR/BPS Guide PHARMACOLOGY, PUBCHEM, RCSB PDB databases server, ligands with suitable...

The focus of DMPK Theme Issues is state of the art and recent developments in research areas that have significant relevance for the academic world as well as for the pharmaceutical industry. The three issues that have appeared to date deal with drug-metabolizing enzymes, membrane transporters and pharmacokinetics and phar-macodynamics. This issue is dedicated to a water-soluble protein transpo...

In-silico ADME and toxcity studies of some novel indole derivativesC. H. S. Venkataramana, K. M. Ramya Sravani, Swetha Singh, V. Madhavan

Submit Manuscript | http://medcraveonline.com Abbreviations: ADME: Absorption, Distribution, Metabolism and Excretion; NDA: New Drug Application; FDA: Food and Drug Administration; CYP: Cytochrome P; UGT: Uridine DiphosphoGlucuronosyl Transferase; NAT: N-Acetyl Transferase; GST: Glutathione S-Transferase; ST: Sulfo Transferase; QSAR: Quantitative Structure–Activity Relationships; PCA: Principal...

The primary objective of this study was to demonstrate the use of stable isotope (SI)-labeled compound as an approach for pharmacokinetic analysis such as fraction absorbed, hepatic extraction ratio, and fraction metabolized from the parent drug to a metabolite. (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride (PNU96391) was selected as the model compound because of its simpl...