objectives juvenile myoclonic epilepsy(j.m.e.) needs life-long anti-epileptic drug (aed) treatment. of various drugs tried in this condition, valproate effectively treats all types of seizures seen in j.m.e. among valproate side effects, neural tube defects (ntd) in the offspring, is a deterring factor in its use in childbearing period. to avoid ntd, most authorities advise on switching to aed ...

In 350 BCE Aristotle wrote about human sleep as ‘‘an inhibition of sense perception’’ for ‘‘conservation.’’ Studies on the effect of sleep and sleep loss began with animals in the 1800s and the 1920s. Kleitman and colleagues explored how sleep and wakefulness relate to circadian rhythms and studied the effects of sleep deprivation. One of Kleitman’s students, William Dement, described the cycli...

Sleep need is characterized by the level of slow-wave activity (SWA) and increases with time spent awake. The molecular nature of this sleep homeostatic process is practically unknown. Here, we show that intracerebroventricular administration of the neuropeptide, cortistatin (CST-14), enhances EEG synchronization by selectively promoting deep slow-wave sleep (SWS) during both the light and dark...

STUDY OBJECTIVE To identify brain regions underlying the fastest and slowest reaction times on the Psychomotor Vigilance task (PVT) under well-rested conditions, as well as brain regions related to particularly poor performance after sleep deprivation. DESIGN Subjects took the PVT twice while undergoing functional magnetic resonance imaging: once 12 hours after waking from a normal night of s...

we investigated the effects of 25 mg-porphyrin-fullerene nanoparticles, ( 25 mgpmc16) smart ferroporphyrin nanoparticles, on pc12 cells exposed to oxygen-glucose deprivation/reperfusion. in order to explore its effect on cells under oxygen-glucose deprivation conditions, the cultures were pretreated with 25 mgpmc16 24 hours prior to oxygen-glucose deprivation/reperfusion. to initiate the oxygen...

The present study focused on investigating the possible neuroprotective potential of peripheral glibenclamide pretreatment and sleep recovery on sleep deprivation effects in rats and the possible mechanisms of action (s). Adult male rats were sleep deprived for a period of 3 days using grid suspended over water method. Morris water maze was used to reveal the effect of both sleep deprivation an...

Acute sleep deprivation can lead to judgement errors and thereby increases the risk of accidents, possibly due to an impaired working memory. However, whether the adverse effects of acute sleep loss on working memory are modulated by auditory distraction in women and men are not known. Additionally, it is unknown whether sleep loss alters the way in which men and women perceive their working me...

Dividing attention across two tasks performed simultaneously usually results in impaired performance on one or both tasks. Most studies have found no difference in the dual-task cost of dividing attention in rested and sleep-deprived states. We hypothesized that, for a divided attention task that is highly cognitively-demanding, performance would show greater impairment during exposure to sleep...

Research Question: How do acute and chronic sleep deprivation affect eating behavior in university students? Does lack of sleep decrease fruit & vegetable intake or increase sweet & starchy food intake? Aims: 1) determine the affect average hours of sleep or acute sleep deprivation (defined as less than 6 hour sleep per night) has on consumption of nutritious foods, measured by examining averag...

Sleep deprivation disrupts hippocampal function and plasticity. In particular, long-term memory consolidation is impaired by sleep deprivation, suggesting that a specific critical period exists following learning during which sleep is necessary. To elucidate the impact of sleep deprivation on long-term memory consolidation and synaptic plasticity, long-term memory was assessed when mice were sl...