The hepato-protective effect of Telfaria occidentalis leaves supplementation on paracetamol induced liver toxicity in wistar rats was investigated. A total forty Wistar (female and male) weighing between 150-250g were selected for the study. animals randomly divided into four groups five each. Animals group 1 2 received standard chow only while 3 4 5% 10% T. their feed respectively six weeks. G...

In this study, the hepatoprotective effect of the methanol extract of aerial parts (shoot) from Otostegia persica Boiss (Golder) was investigated against the carbon tetrachloride (CCl4)-induced acute hepatotoxicity in male rats. Liver damage was induced through the oral administration of 50% CCl4 in liquid paraffin (2.5 mL/Kg bw, per os) 60 min after the administration of the methanol extract o...

Herbs are known to play a vital role in the management of various liver diseases. Thymoquinone (TQ) is the bioactive constituent of Nigella sativa seed. The present work was planned to evaluate the potential hepatoprotective effects of TQ against the cytotoxic effects and the oxidative stress induced by carbon tetrachloride (CCl4) in isolated primary rat hepatocytes. Cytotoxicity was determined...

Objective: To evaluate the glutathione (GSH), lipid peroxidation, total antioxidant status levels (TAS), and liver function parameters such as serum aspartate transaminase (AST) and serum alanine transaminase (ALT) in South Indian hypertensive patients before and after olmesartan and labetalol treatment. Methods: Total 69 subjects were selected for the study. Out of 69 subjects, 29 were healthy...

OBJECTIVE Recently, a positive correlation between alanine transaminase activity and body mass was established among healthy young individuals of normal weight. Here we explore further this relationship and propose a physiological rationale for this link. DESIGN Cross-sectional statistical analysis of adiposity across large samples of adults differing by age, diet and lifestyle. SUBJECTS 46...

Torque Teno virus (TTV) is a transfusion transmitted virus that seems to be involved in several complications such as acute respiratory diseases, liver diseases, AIDS, cancer, and autoimmune reactions.  In the present study the frequency of TTV was investigated among β- thalassemia (BT) and haemodialysis (HD) patients (high risk patients for TTV) in Mazandaran province, Iran. DNA was ...

Patulin (PAT) is a mycotoxin produced by certain species of Penicillium, Aspergillus, and Byssochlamys. Previous studies demonstrated its cytotoxic, genotoxic, and mutagenic effects in different cell lines. However, there is little information available concerning its toxic behavior in vivo. In the present study, we investigated PAT-induced hepatotoxicity and genotoxicity in mice. We also inves...

The objective of the present study appraised the hepatoprotective activity of methanolic extract of Melia azedarach. L leaves on Wistar rats. The Methanolic extracts of Melia azedarach. L (200mg & 500mg/kg,b.w,p.o) was administered respectively to the animals which were treated with carbon tetrachloride. Its effects on biochemical parameters were compared with standard drug silymarin (100mg/kg,...

In order to assess the potency of aqueous stem bark extract of Khaya senegalensis (KS) against liver diseases, serum aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) were assayed in rats treated with two (2) different doses of the extract after the induction of liver damage in the rats using carbon tetrachloride, CCl4. The rats treated with a daily dose of...