Background: Albumin is known as a human blood product, with high cost and limited availability. Several studies have demonstrated the extent in which albumin is being utilized in controversial indications not supported or weakly supported by the available literature. Objective: To rationalize the use of albumin and to decrease the inappropriate cost of this expensive drug. Methods: A two phase...

introduction: ramadan is the ninth month of the lunar islamic calendar, during which muslims are obliged to perform specific rites and rituals. fasting is considered the most important ritual during the holy month of ramadan. fasting variably influences the health of individuals, which could be attributed to the changes in the concentrations of certain biochemical markers. this study aimed to e...

several cell lines (18) of poorly differentiated rat ascites hepatomas which grown intraperitoneally were analyzed with respect to their mrna levels of gst-p and albumin. the expression of albumin was dramatically decreased and became undetectable in all of the examined hepatomas compared with normal rat liver. the gst-p mrna level in the hepatomas was correlated with their ability for formatio...

advanced glycation end-products (ages) are formed by non-enzymatic reaction between reducing sugar and protein. ages play important roles in pathogenesis of diabetic, aging complications, endothelial dysfunction and neurological diseases such as the alzheimer’s disease. therefore compounds that prevent the glycation reaction are purported to have therapeutic effect on patients with diabetes and...

Human serum albumin has been used as a model protein for protein folding and ligand binding studies over many decades. Due to its long life period and high concentration in plasma, HSA is highly sensitive to glycation. It is reported that 175 mg/dL glucose concentration is a threshold of kidney activity for the beginning of excretion of glucose. pH denaturation of HSA in absence and presence of...

human serum albumin has been used as a model protein for protein folding and ligand binding studies over many decades. due to its long life period and high concentration in plasma, hsa is highly sensitive to glycation. it is reported that 175 mg/dl glucose concentration is a threshold of kidney activity for the beginning of excretion of glucose. ph denaturation of hsa in absence and presence of...