This is the first report of sphingosine 1-phosphate lyase (SPL) protein expression and enzymatic activity in human neoplasm. This enzyme drives irreversible degradation of sphingosine 1-phosphate (S1P), a bioactive lipid associatedwith resistance to therapeutics in various cancers, including prostate adenocarcinoma. In fresh human prostatectomy specimens, a remarkable decrease in SPL enzymatic ...

Software product line modeling aims at capturing a set of software products in an economic yet meaningful way. We introduce a class of variability models that capture the sharing between the software artifacts forming the products of a software product line (SPL) in a hierarchical fashion, in terms of commonalities and orthogonalities. Such models are useful when analyzing and verifying all pro...

Measures of the sound pressure level (SPL) near the eardrum were determined at discrete frequencies between 500 and 4000 Hz on 50 ears using TDH-39P and ER-3A earphones with the attenuator of an audiometer fixed at 90 dB HL. Results revealed significant differences in the measured SPL between the two earphones at all test frequencies. Results also revealed large intersubject differences in the ...

Unit testing is an attractive quality management tool in the software development process, however, practical obstacles make it difficult to use unit tests for performance testing. We present Stochastic Performance Logic, a formalism for expressing performance requirements, together with interpretations that facilitate performance evaluation in the unit test context. The formalism and the inter...

OBJECTIVES This study was designed to assess the impact of 2 years of operatic training on acoustic and aerodynamic characteristics of the singing voice. STUDY DESIGN This is a longitudinal study. METHODS Participants were 21 graduate students and 16 undergraduate students. They completed a variety of tasks, including laryngeal videostroboscopy, audio recording of pitch range, and singing o...

Sphingosine-1-phosphate lyase (SPL), a key enzyme of sphingolipid metabolism, catalyzes the irreversible degradation of sphingoid base phosphates. Its main substrate sphingosine-1-phosphate (S1P) acts both extracellularly, by binding G protein-coupled receptors of the lysophospholipid receptor family, and inside the cell, as a second messenger. There, S1P takes part in regulating various cellul...

Existing economic models support the estimation of the costs and benefits of developing and evolving a Software Product Line (SPL) as compared to undertaking traditional software development approaches. In addition, Feature Diagrams (FDs) are a valuable tool to scope the domain of a SPL. This paper proposes an algorithm to calculate, from a FD, the following information for economic models: the...

Thermodynamics problems for the single-phase-lagging (SPL) model have not been much studied. In this paper, the violation of the second law of thermodynamics by the SPL model is studied from two perspectives, which are the negative entropy production rate and breaking equilibrium spontaneously. The methods for the SPL model to avoid the negative entropy production rate are proposed, which are e...

Software Product Line (SPL) is a software engineering paradigm that is inspired by the concept of reusability of common features, formulated for different software products. Complete testing of all software products in SPL is known to be unfeasible. This is due to the very large number of possible products that can be produced or configured using a combination of features in the SPL. Pairwise T...