This work examines the molecular mechanism of action of a class of bactericidal gold nanoparticles (NPs) which show potent antibacterial activities against multidrug-resistant Gram-negative bacteria by transcriptomic and proteomic approaches. Gold NPs exert their antibacterial activities mainly by two ways: one is to collapse membrane potential, inhibiting ATPase activities to decrease the ATP ...

Hydroxamic acids demonstrated mutagenic and antibacterial activities. These activities appear to be dependent on the hydroxamic acid function and are probably due to the interaction with deoxyribonucleic acid.

Due to the increasing emergence of drug resistant Tuberculosis (TB), particularly multidrug resistant TB (MDR-TB), extensive-drug resistant TB (XDR-TB) and also the development of resistance in the micro-organisms against available drugs there is a need to develop new, potent, fast-acting antibacterial and antitubercular drugs with low toxicity. With this aim different extracts of Phaseolus vul...

A series of pleuromutilin derivatives were synthesized by two synthetic procedures under mild reaction conditions and characterized by Nuclear Magnetic Resonance (NMR), Infrared Spectroscopy (IR), and High Resolution Mass Spectrometer (HRMS). Most of the derivatives with heterocyclic groups at the C-14 side of pleuromutilin exhibited excellent in vitro antibacterial activities against Staphyloc...

The aim of the present study was to develop drug immunoconjugates (DIC) of antibiotics like Ampicillin trihydrate, Amoxycillin trihydrate, Streptomycin sulphate, Rifampicin and doxorubicin with Anti-D serum using different coupling methods. Protein content in AntiD serum was estimated by Lowry’s method. The conjugates were purified from unbound drug by dialysis. The drugs to antibody ratios wer...

Removing the bacteria, including Enterococcus faecalis, from the root canal is one of the important aims in endodontic treatment.We aimed to compare the antibacterial activity of Chlorhexidine with two natural drugs. The antibacterial activities of three different propolis extracts (alcohol concentrations: 0, 15, 40%) and Aloe vera gel on E. faecalis were compared using three methods: disk diff...

the essential oil of verbena officinalis growing in iran was extracted using hydro-distillationmethod and the antibacterial and antioxidant activities were evaluated. the antibacterial activity of the essentialoil against a gram-positive (s. aureus atcc25923) and gram negative (e. coli atcc 25922) were examined.the results obtained revealed that the essential oil exhibited variable levels of an...

In the present study, we reported the essential oils chemical composition and antibacterial activities of the aerial parts of Ajuga chamaecistus Ging. ex Benth. Subsp. Scoparia (Boiss.) Rech.f. thatwere collected duringMay 2013 and April 2014 and extracted by SDE (simultaneous distillation–extraction) and Clevenger apparatus. GC/MS analysis of the plant essential oils led to the identification ...