Epigenomic profiling has revealed that substantial portions of genomes in higher eukaryotes are organized into extensive domains of transcriptionally repressive chromatin. The boundaries of repressive chromatin domains can be fixed by DNA elements known as barrier insulators, to both shield neighboring gene expression and to maintain the integrity of chromosomal silencing. Here, we examine the ...

the purpose of this study is pathology of talent management in the automotive industry, so we identify challenges and barriers, as well as success factors in this filed. this research is a kind of qualitative study that has been done by coding methodology of qualitative data. we used semi-structured interview to collect data. after collecting data and coding, data are divided into two groups of...

multiple sclerosis (ms) is an inflammatory disorder, in which neurons become demyelinated. to date, its etiology has remained unknown. nevertheless, certain features are inspected to provoke ms. for instance, improper function of immune cells is widely believed to be the basis of such disorder. in this concept, ms is stated as an autoimmune disease, which was asserted by major of studies, as cd...

background: family planning is a lifestyle that is selected voluntarily and is based on the knowledge, attitude and responsible decision making by couples in order to promote the health and welfare of the family and the advancement of the society. in this regard, family planning counseling plays an important role in making informed decisions if used properly and in a responsible way. detection ...

The complexity of ERP implementation can create high profile failures. Technology transfer scholars identify a difference in culture, either organizational or national, as a potential barrier to successful implementation of any complex technology. We explore this barrier to ERP system quality and consider user support, top management support and consultant quality as possible factors for success.

the present paper explores the barriers to the supply chain of the lightweight construction in the automotive industry in zahedan. the aim of the study is to identify the barriers and the key performance of the automotive supply chain to help develop the production so as to achieve, in this way, higher quality products in less time and high customer satisfaction. to this end, the factors affect...

Stabilization of the blood-brain barrier during and after stroke can lead to less adverse outcome. For elucidation of underlying mechanisms and development of novel therapeutic strategies validated in vitro disease models of the blood-brain barrier could be very helpful. To mimic in vitro stroke conditions we have established a blood-brain barrier in vitro model based on mouse cell line cerebEN...

When quadrupeds stop walking after stepping over a barrier with their forelegs, the memory of barrier height and location is retained for many minutes. This memory is subsequently used to guide hind leg movements over the barrier when walking is resumed. The upslope of the initial trajectory of hind leg paw movements is strongly dependent on the initial location of the paw relative to the barri...