Pseudomonas aeruginosa is one of the most common causes of keratitis. The current study was done to evaluate the therapeutic effects of antibacterial combinations with Silver nanoparticles (Ag-NPs) and Ciprofloxacin in experimental Pseudomonas keratitis. Sixty four New Zealand rabbits were prepared. All rabbits were randomly categorized into eight groups (each group containing eight rabbits): C...

L ipoatrophy has been reported in association with the use of human insulin analogs (1). We report on a girl with severe lipoatrophy who was treated with betamethasone added to the insulin analog, after which the areas of lipoatrophy improved. A 7-year-old girl with type 1 diabetes, treated with insulin-aspart by continuous subcutaneous insulin infusion, developed areas of lipoatrophy at her in...

Antenatal corticosteroids may have long-term effects on renal development which have not been clearly defined. Our objective was to compare the responses to intrarenal infusions of ANG II in two groups of year-old, male sheep: one group exposed to a clinically relevant dose of betamethasone before birth and one not exposed. We wished to test the hypothesis that antenatal steroid exposure would ...

Twelve patients with chronic severe asthma, having previously shown an FEV1 increase of less than 20% of the predicted value with prednisolone treatment (20-60 mg daily for 10 days), took part in a double blind crossover comparison of equipotent anti-inflammatory doses of betamethasone and prednisolone. Betamethasone (8 mg) and prednisolone (40 mg) were administered daily for 10 days with a was...

Objective: Evaluating the effect of antenatal betamethasone on the biophysical profile and Doppler indices of umbilical and middle cerebral arteries. Materials and Methods: Twenty-five preterm labor singleton pregnancies (gestational age, 26-34 weeks) were studied prospectively. These patients received two consecutive doses of betamethasone 24 hours apart to accelerate pulmonary maturation. Fet...

INTRODUCTION A combination of antihistamines and oral corticosteroids is often used to treat acute symptoms of allergic rhinitis. OBJECTIVE To evaluate safety and efficacy of desloratadine plus prednisolone in the treatment of acute symptoms of children (2-12 years) with allergic rhinitis, and to compare it to dexchlorpheniramine plus betamethasone. METHODS Children with moderate/severe per...

BACKGROUND Preterm labor is the most common complication of the pregnancy in the second trimester and has been suggested as the cause of two-thirds of neonatal mortality. Antenatal corticosteroid is used for fetal lung maturity in preterm labor and makes a significant reduction in the incidence of respiratory distress syndrome (RDS). The aim of this study was to compare the prenatal administrat...

Fetal exposure to synthetic glucocorticoids in sheep results in increased fetal hypothalamic-pituitary-adrenal (HPA) activity persisting to one year of age. We aimed to determine the effects of single or repeated maternal or fetal betamethasone injections on offspring HPA activity at 2 and 3 yr of age and whether changes in adrenal mediators of steroidogenesis contribute to changes in pituitary...

Glucocorticoids prevent or suppress the full inflammatory response to infectious, immunological physical agents by inhibiting early events such as edema cell exudation. The main effect of glucocorticoids on process is inhibition recruitment neutrophils and monocytes. In this study, glucocorticoid betamethasone hematological parameters rats species Rattus norvegicus Berkenhout 1769 was examined ...

A new RP-HPLC method was developed for selective and simultaneous determination of betamethasone dipropionate and tolnaftate in combined semisolid formulation containing other components. Further, the proposed method was validated for linearity, precision (system precision, method precision, intermediate or inter-day precision), accuracy, stability in analytical solution, robustness or system s...