Impaired reparative processes in particular related to hyaluronan in various cutaneous disorders-A structural analysis Ulf Bertheim Umeå 2004 2 Cover illustration Colour light micrograph of histological section from normal skin stained with HABP (brown), demonstrating the distribution of hyaluronan (HA). (Photo; Dr Ulf Bertheim) The PD is intensely stained with an intense, uniform appearance of...

objective(s): the periodic binding of protein expressed by mycobacterium tuberculosis h37rv with the host cell receptor molecules i.e. fibronectin (fn) is gaining significance because of its adhesive properties.  the genome sequencing of m. tuberculosis h37rv revealed that the proline-glutamic (pe) proteins contain polymorphic gc-rich repetitive sequences (pgrs) which have clinical importance i...

Protein aggregation is phenomenon wherein protein loses its native structure and aggregates due to the adaption of non-native conformation. Amyloid aggregation formed by the accumulation of various proteins causes many diseases in humans and other organisms. Antioxidants can prevent proteins aggregation. Pulicaria undulata  extract along with phenolic compounds can increase protein stability an...

Hospital-acquired bacterial pneumonia (HABP) is one of the most important causes of morbidity, mortality and economic problems especially for patients admitted in the intensive care unit (ICU) ward. The aim of this study was to determine the incidence of nosocomial pneumonia in ICU, identify the causative bacteria and their resistance profiles. This cross sectional study was performed on 214 pa...

calcium-binding proteins play essential roles in the cell. one important class of calcium-binding proteins is the annexin family. this is a family of 13 proteins, which binds to phospholipids in a calcium-dependent manner. osteosarcoma cell line (mg-63) is a transformed cell that has many characteristics of the differentiated cell, such as a considerable serum dependency in its growth rate. usi...

Enzymes play a central role in the detection of target molecules biotechnological fields. Most probes used are bifunctional proteins comprising enzymes and binding conjugated by chemical reactions. To create highly sensitive probe, it is essential to increase enzyme-to-binding protein ratio probe. However, if reactions required prepare probe insufficiently site-specific, may lose functionality....

Living organisms can sense and respond to external and internal stimuli. Response isdemonstrated in many forms including modulation of gene expression profiles, motility,secretion, cell death, etc. Nevertheless, all forms share a basic property: they depend on sensingsmall changes in the concentration of an effector molecule or subtle conformational changes ina protein and invoking the appropri...

Virus capsid proteins modified with a heparin binding peptide can selectively bind and encapsulate inside protein cage.