نتایج جستجو برای: biological response modifiers
تعداد نتایج: 1383692 فیلتر نتایج به سال:
Safety and quality of food and feed in Europe today is at a high level, the challenge is to ensure a healthy daily diet but affordable for everyone. Plant breeding and development of functional food ingredients contribute to the production of high quality food and thus to ensure a healthy diet for the entire population in a sustainable manner, while a more efficient processing and distribution ...
[This corrects the article DOI: 10.1371/journal.pone.0145902.].
This summary provides an overview of investigational antiviral agents for influenza and of future directions for development of influenza therapeutics. While progress in developing clinically useful antiviral agents for influenza has been generally slow, especially with respect to seriously ill and high-risk patients, important clinical studies of intravenous neuraminidase inhibitors, antibodie...
Spontaneous disease extinction can occur due to a rare stochastic fluctuation. We explore this process, both numerically and theoretically, in two minimal models of stochastic viral infection dynamics. We propose a method that reduces the complexity in models of viral infections so that the remaining dynamics can be studied by previously developed techniques for analyzing epidemiological models...
While 30%-70% of RSV-infected infants develop bronchiolitis, 2% require hospitalization. It is not clear why disease severity differs among healthy, full-term infants; however, virus titers, inflammation, and Th2 bias are proposed explanations. While TLR4 is associated with these disease phenotypes, the role of this receptor in respiratory syncytial virus (RSV) pathogenesis is controversial. He...
Vaccines aim to protect against or treat diseases through manipulation of the immune response, promoting either immunity or tolerance. In the former case, vaccines generate antibodies and T cells poised to protect against future pathogen encounter or attack diseased cells such as tumours; in the latter case, which is far less developed, vaccines block pathogenic autoreactive T cells and autoant...
PURPOSE OF REVIEW A host of immune modulators are now available in clinical practice. The perioperative period is characterized by profound alterations in host immunity, which can result in poor outcomes, which include infection, cancer recurrence and organ failure. Manipulation of the perioperative immune response has the potential to improve outcomes. A complete understanding of the mechanism...
Despite remarkable advances in therapy, rheumatoid arthritis (RA) still results in significant morbidity, mortality, and disability [1]. In addition to symmetrical joint swelling of the feet and hands, large joints such as the shoulders, hips, knees, and cervical spine can be affected. RA also may affect the pulmonary, cardiovascular, and ocular systems. Rheumatoid factor is present in up to 80...
Periodontal diseases are characterized by a complex set of biologic interactions between a diverse and dynamic microbial ecosystem and the host's multifaceted and responsive immune and inflammatory machinery. Such interactions between microbial pathogens and various host response systems play a critical role in the development and progression of periodontal disease via the release of inflammato...
Therapeutic cancer vaccines have the potential to generate a long lasting immune response that will destroy tumor cells with specificity and safety, in contrast to many other current cancer therapies. Clinical success to date has been limited by a number of factors including choice of immunogenic cancer rejection antigens, optimization of vaccine platforms and immune adjuvants to effectively po...
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