there is a continuing need to identify new agents that are active in ovarian cancer. etoposide is a derivative of the plant alkaloid epipodophyllotoxin. the availability of etoposide in oral preparation allows prolonged administration by the oral route. in this study, activity and toxicity of etoposide in women with recurrent ovarian cancer are described from a case series of women with recurre...

Head and neck cancer is treated mainly by surgery and radiotherapy. Normal tissue toxicity due to x-ray exposure is a limiting factor for treatment success. Many efforts have been employed to develop predictive tests applied to clinical practice. Determination of lymphocyte radio-sensitivity by radio-induced apoptosis arises as a possible method to predict tissue toxicity due to radiotherapy. T...

Various studies on Phragmanthera incana (mistletoe) did not intensify toxicity. Toxicological evaluation of Phragmanthera incana, a species of mistletoe growing on two plant hosts namely Cocoa (Theobroma cacao) and Kolanut (Cola nitida) in South-western Nigeria was carried out with the observation of Wistar rats’ haematological and serum biochemical changes for a period of thirty-day administra...

Introduction: The search for and development of new highly active medications their combinations the appropriate direction action remains an urgent problem due to complications diabetes mellitus, especially burdened with atherosclerosis, including skin vascular lesions.
 Materials methods: acute toxicity, histoprotective dermatoprotective effects mafusol, rexod, alprostadil were studied in...

Background: Rosa damascena is a traditional medicinal plant used in Asia to treat several ailments. This study reports In vitro and In vivo antioxidative properties and toxicity of methanolic and aqueous extracts of white rose, an indigenous variety of Rosa damascena from Iran. Methods: The antimicrobial activities, total phenolics, antioxidative properties and the blood sera Ferric-Reducin...

background: lead toxicity has been reported to affect hematopoietic, nervous, reproductive, cardiovascular and urinary tract systems. many investigators have so far studied the effects of high blood lead levels on pregnancy outcomes. objective: to investigate the effects of elevated maternal blood lead during pregnancy on some trace elements and pregnancy outcomes. methods: blood lead and plasm...

Background: Carissa edulis is widely used in traditional medicine to manage numerous ailments. However, few studies have assessed its toxicity. Therefore, this study aimed determine acute and sub-toxicity levels of C. methanol extract. Methods: In the toxicity probe, a limit test was conducted whereby extract given as solo dose by gavage. The rats were observed for two weeks. observations inclu...

Food and drug control authorities in each country have issued warnings about the toxic effect potential of using commonly consumed traditional medicines. The safety assurance, standardization, market regulation herbal medicines being sold need to be determined. This study's goal is investigate acute subchronic toxicity cold-processed snakehead fish (Channa striata) flesh. In-vivo rats models we...

objective(s):  there is a rising use of gold nanoparticles (aunps) in goods and in the medical fields but there is concern about the toxicity of them. so in this study spherical aunps with 3 different concentrations were applied for investigating their effects in vivo.   materials and methods:  40 male albino mice were randomly divided into sham, control, 25 ppm, 50 ppm, 100 ppm groups and were...