In this issue of Cell Stem Cell, Hormaechea-Agulla et al., 2021Hormaechea-Agulla D. Matatall K.A. Le D.T. Kain B. Long X. Kus P. Jaksik R. Challen G.A. Kimmel M. King K.Y. Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFN? signaling.Cell Cell. 2021; (Published online March 19, 2021)https://doi.org/10.1016/j.stem.2021.03.002Abstract Full Text PDF Scopus (45) Google Sc...

waste tires, rubbers, plastic and steel materials, normally produced in every society, enter the environment and cause serious problems. these problems may, to some extent, be reduced by finding applications for them in engineering, for example, they can be used for geotechnical applications as backfill material and solving problems with low shear strength soils. such materials may be subjected...

Bone graft materials are widely used in reconstructive orthopedic procedures to promote new bone formation and bone healing, provide a substrate and scaffolding for development of bone structure, and function as a means for direct antibiotic delivery. Bone graft materials include autografts, allografts, and synthetic substitutes. An autograft (from the patient's own bone) supplies both bone vol...

A highly osteogenic hybrid bioabsorbable scaffold was developed for bone reconstruction/augmentation. Through the use of a solid free-form fabrication technology, a bioabsorbable polycaprolactone (PCL) cage scaffold with a desired size and shape was produced and then filled with osteogenic bone graft particles, that is, morselized autologous bone chips. A rabbit total lamina defect model was ch...

In this study, changes in some quality parameters of fish chips produced from sand smelt (Atherina boyeri, RISSO 1810) during storage period (at -18  o C for 6 months) were determined.  The difference between the amount of moisture, crude protein, crude fat and crude ash components of raw fish in fish chips was significant (P < 0.05). Pre-frying  process resulted in a decrease in all fatty acid...

Craniectomy is a life-saving procedure. Subsequent cranioplasty with autologous skull bone has a bone resorption rate from 4% to 22.8% and an infection rate from 3.3% to 26%. There are concerns with their viability and the potential microbial contamination as they were explanted for a long period of time. Eighteen cranial bone flaps stored at Prince of Wales Hospital Skull Bone Bank during the ...

BACKGROUND Bone grafts from bone banks might be mixed with bisphosphonates to inhibit the osteoclastic response. This inhibition prevents the osteoclasts to resorb the allograft bone before new bone has been formed by the osteoblasts, which might prevent instability. Since bisphosphonates may not only inhibit osteoclasts, but also osteoblasts and thus bone formation, we studied different bispho...

PURPOSE The off-label use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for the treatment of mandibular bone defects was evaluated in 5 patients. The rhBMP-2 was used as an alternative to autogenous bone grafting. PATIENTS AND METHODS A total of 5 patients had mandibular defects reconstructed with rhBMP-2, 1.5 mg/mL, soaked collagen sponges alone or in combination with bone marr...