CONTEXT Although muscle mass is beneficial to bone, studies on the effect of fat mass on bone have yielded conflicting results. OBJECTIVE The aim of this study was to assess the relations between lean and fat mass and bone structure. DESIGN This study was cross-sectional. SETTING The study was conducted in a general community. SUBJECTS Subjects included 300 healthy sexually mature adole...

Osteoporosis is a systemic skeletal disorder characterized by reduction of one mass, deterioration of bone structure, increase of bone fragility, and fracture risk increment. The purpose of this study was to investigate the effect of an educational program based on Health Melief Model (HBM) onosteoporosis and Bone Mineral Density (BMD) in women. In this quasi-experimental study, 160 participant...

Bone mass accrual is a major determinant of skeletal mass, governed by bone remodeling, which consists of bone resorption by osteoclasts and bone formation by osteoblasts. Bone mass accrual is inhibited by sympathetic signaling centrally regulated through activation of receptors for serotonin, leptin, and ACh. However, skeletal activity of the parasympathetic nervous system (PSNS) has not been ...

Bone is composed of an organic matrix of type I collagen associated with non-collagenous proteins and a large mineral component consisting of calcium hydroxyapatite. To date, measurement of bone mass only takes into account the mineral component of bone, while recognizing that the organic matrix is important in providing both structure and strength. The present paper will concentrate on the inf...

OBJECTIVE To evaluate the influence of body composition on bone mass in children and adolescents. METHODS A cross-sectional study with 267 healthy students of both sexes (141 males and 126 females) aged 8 to 18 years. Weight, height, body mass index, lean mass, fat mass, fat mass index, body fat percentage, waist and hip circumferences, and waist-to-hip ratio were evaluated. Bone mass was ass...

BACKGROUND To compare the relationship of skeletal muscle mass with bone mineral content in an ethnically diverse group of 6 to 18 year old boys and girls. METHODS 175 healthy children (103 boys; 72 girls) had assessments of body mass, height, and Tanner stage. Whole body bone mineral content, non-bone lean body mass (nbLBM), skeletal muscle mass, and fat mass were assessed using dual-energy ...

The available data indicate that HIV-infected children and adolescents have reduced bone mass compared to healthy peers. The increased survival due to the control of HIV infection by potent antiretroviral treatment, exposes patients to the achievement of a reduced peak bone mass and to an increased fracture risk during adult life. Reduced bone mass in HIV-infected children is the result of alte...

ObjectiveTo evaluate bone mineral mass in adolescents with failure to thrive in relation to body composition.MethodsA case control study involving 126 adolescents (15 to 19 years), in final puberty maturation being 76 eutrophic and 50 with failure to thrive (genetic or constitutional delay of growth), of matching ages, gender and pubertal maturation. The weight, height and calculated Z score fo...

We investigated the role of Lef1, one of the four transcription factors that transmit Wnt signaling to the genome, in the regulation of bone mass. Microcomputed tomographic analysis of 13- and 17-week-old mice revealed significantly reduced trabecular bone mass in Lef1(+/-) females compared to littermate wild-type females. This was attributable to decreased osteoblast activity and bone formatio...