The left cerebral hemisphere of Mongolian gerbils was used to elucidate the mechanisms of brain edema which develop during cerebral ischemia and after restoration of cerebral blood flow following temporary ischemia. Water content was measured by the tissue-drying method. Sodium and potssium ion concentration was measured by flame photometry. Passage of 131I-albumin (RISA) from blood to the cere...

BACKGROUND AND PURPOSE Individualizing mean arterial blood pressure targets to a patient's cerebral blood flow autoregulatory range might prevent brain ischemia for patients undergoing cardiopulmonary bypass (CPB). This study compares the accuracy of real-time cerebral blood flow autoregulation monitoring using near-infrared spectroscopy with that of transcranial Doppler. METHODS Sixty adult ...

Objective(s): Multifunctional nanomedicine is the new generation of medicine, which is remarkably promising and associated with the minimum toxicity of targeted therapy. Distribution and transport of nanoparticles (NPs) in the blood flow are essential to the evaluation of delivery efficacy. Materials and Methods: In the present study, we initially designed a phantom based on Murray’s mini...

It has been shown that cerebral oxygen consumption and blood flow are normal and cerebral vascular resistance is increased in patients with essential hypertension (1). Clinicians have questioned the advisability of lowering arterial pressures in hypertensive patients because of the possible untoward effects consequent to decreased cerebral blood flow (2, 3). We have studied the effect of hypote...

To determine whether expansion of blood volume improves vital organ perfusion pressures and blood flow during closed-chest cardiopulmonary resuscitation in dogs, we recorded intracranial and high-fidelity ascending aortic and right atrial pressures and measured total and regional blood flow with radioactive microspheres during cardiopulmonary resuscitation before and after rapid infusion of 1 l...

1. Cerebral blood flow, oxygen and glucose consumption, hind-limb blood flow and oxygen consumption, blood pressure and heart rate were measured in seven ventilated dogs. 2. Inhalation of 5% C 0 2 caused a significant increase in cerebral blood flow and a significant decrease in cerebral glucose utilization. 3. Isoprenaline infusion (0.4 pg kg-I min-') caused a rise in cerebral blood flow, oxyg...

339 The Framingham study and the epidemiology of stroke.iate analysis of risk factors for stroke: Eight-year follow-up study of farming villages in Akita, Japan.WHEN A MAJOR CEREBRAL ARTERY is abruptly occluded, many factors play a role in determining whether damage to the brain will occur. The adequacy of collateral circulation governs the severity and extent of ischemia.' The duration of isch...