In the last decades the prevalence of non-alcoholic fatty liver disease (NAFLD) has increased as a consequence of the childhood obesity world epidemic. The liver damage occurring in NAFLD ranges from simple steatosis to steatohepatitis, fibrosis and cirrhosis. Recent findings reported that fatty liver disease is related to early atherosclerosis and cardiac dysfunction even in the pediatric popu...

covered at the post-mortem examination. The woman was sixty years of age, and showed signs of general atheroma. There was no history of injury, but most of her organs were more or less diseased, and she appears to have died from a combination of pleural effusion and hepatic cirrhosis. Dr. Joseph Walsh contributes an interesting paper on Pertussis, one of the gravest troubles of childhood. Unfor...

Ultrastructural features of the liver in eight cases of Indian childhood cirrhosis, a fatal and elusive liver disease in India, have been described. Severe parenchymal damage, diffuse creeping fibrosis, and other light microscopic alterations, including the frequent presence of cytoplasmic hyaline, reported earlier are confirmed in the present study. The hyaline is predominantly comprised of ta...

background serum apoptotic cytokeratine 18 neoepitope m30 (ck-18 m30) and matrix metalloproteinase 2 (mmp-2) have been popular markers for detecting liver fibrosis in recent years. ck-18 is a major intermediate filament protein in liver cells and one of the most prominent substrates of caspases during hepatocyte apoptosis. mmp-2 plays an important role in tissue remodeling and repairing process...

Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver, characterized by the presence of antimitochondrial antibodies (AMA) and progressive immune-mediated destruction of biliary ductules, which lead to cirrhosis. Theories of the PBC etiopathogenesis assume that the disease develops secondarily as an improper immunological reaction to undefined environmental and/or infectious fac...

background there have been very few studies evaluating the close association between excess iron and cirrhosis; however, cirrhosis could be regarded as an iron-loading disorder. objectives in this study, the goal was to show the levels of the iron content in the liver tissue in certain types of cirrhosis. patients and methods in this 7 year study (2008 - 2014), in 1000 explanted livers, the amo...