Drug-induced cholestasis is the main type of liver disorder accompanied by high morbidity and mortality. Evidence for the role of hepatobiliary pumps in the cholestasis patho-mechanism is constantly increasing. Recognition of the interactions of chemical agents with these transporters at the initial phases of drug discovery can help develop new drug candidates with low cholestasis potential. Th...

Cholestasis activates bile acid receptor farnesoid X receptor (FXR) and subsequently enhances hepatic expression of small heterodimer partner (SHP). We previously demonstrated that SHP represses the transactivation of cytochrome P450 2D6 (CYP2D6) promoter by hepatocyte nuclear factor (HNF) 4α. In this study, we investigated the effects of estrogen-induced cholestasis on CYP2D6 expression. Estro...

Under the conditions of a chronic methionine diet (daily addition amino acids to food (0.15 g/100 g) and water (1% solution)) during 2–12 weeks, dynamics liver tests, infl ammatory changes in blood lipids was monitored. It found that (MD) leads, starting from 4 weeks MD, medium hyperhomocysteinemia, an increase enzymes (AsAT – 1.73, AlAT 1.5 times, p<0.05) bilirubin (by 62.25%), which indica...

Sickle cell disease can lead to hepatic complications ranging from acute hepatic crises to chronic liver disease including intrahepatic cholestasis, and iron overload. Although uncommon, intrahepatic cholestasis may be severe and medical treatment of this complication is often ineffective. We report a case of a 37 year-old male patient with sickle cell anemia, who developed liver failure and un...

To assess the extent of microfilaments in cholestatic liver diseases we examined the cytoplasmic microfilaments in intrahepatic and extrahepatic cholestasis in man by electron microscopy. Study subjects were two patients with drug-induced intrahepatic cholestasis, three patients with intrahepatic cholestasis due to viral hepatitis, four patients with extrahepatic cholestasis due to stones of th...

The Liver and Hepatobiliary System Metabolic Functions of the Liver Carbohydrate, Protein, and Lipid Metabolism Drug and Hormone Metabolism Bile Production and Cholestasis Cholestasis Bilirubin Elimination Tests of Hepatobiliary Function Disorders of the Liver Hepatitis Acute Viral Hepatitis Chronic Hepatitis Intrahepatic Biliary Disorders Primary Biliary Cirrhosis Primary Sclerosing Cholangiti...

Drug-induced cholestasis is the main type of liver disorder accompanied by high morbidity and mortality. Evidence for the role of hepatobiliary pumps in the cholestasis patho-mechanism is constantly increasing. Recognition of the interactions of chemical agents with these transporters at the initial phases of drug discovery can help develop new drug candidates with low cholestasis potential. Th...

Introduction: Neonatal cholestasis due to endocrine diseases is infrequent and poorly reco­ gnized. Referral to the pediatric endocrinologist is delayed. Objective: We characterized cholestasis in infants with congenital pituitary hormone deficiencies (CPHD), and its resolu­ tion after hormone replacement therapy (HRT). Subjects and methods: Sixteen patients (12 males) were included; eleven wit...

Autoimmune cholangitis is a clinical constellation of chronic cholestasis, histological changes of chronic nonsuppurative cholangitis and the presence of autoantibodies other than antimitochondrial antibody (AMA). It is uncertain whether this entity is definitely different from AMA positive primary biliary cirrhosis (PBC), though it shows some differences. We report a case of autoimmune cholang...