نتایج جستجو برای: chronic myelogenous leukaemia
تعداد نتایج: 508249 فیلتر نتایج به سال:
Interferon has been shown to have an antiproliferative effect on leukaemic blast cells in vitro [ l , 3, 41. In short-term liquid culture, 50% inhibition of growth is achieved at IFN-a concentrations of 103 units/ml using myeloblasts derived from patients with acute myelogenous leukaemia (AML) [5]. Pharmacokinetic studies in patients receiving IFN-a by continuous intravenous infusion (i.v.i) ha...
Granulocytic sarcoma of the small intestine: an unusual presentation of acute myelogenous leukaemia.
Granulocytic sarcoma is an extramedullary tumour of primitive granulocytic cells. It can develop at any anatomic site and is often a forerunner to the development of acute myelogenous leukaemia. Granulocytic sarcoma of the small intestine presents with abdominal pain and obstruction. We report a case of a 17-years-old boy who presented with epigastric pain. His endoscopy revealed multiple polyp...
conclusions both the cases discussed in our study have inv(9) as the sole abnormality and are found to confer a relatively poor prognosis. case presentation we present the case of a chronic myeloid leukemia (cml) patient who showed intermittent relapse on treatment, with a rare appearance of clones with dual inversion (9) breakpoints [inv(9)(p22q34); inv(9)(p11q21)]. we also present the first r...
isolated extramedullary relapse of chronic myelogenous leukemia (cml) after allogeneic stem cell transplant is rare. there is a case report of a child who developed a granulocytic sarcoma of the maxillary and sphenoid sinuses and lumbosacral spinal cord mass 18 months after allogeneic bone marrow transplant for cml. he was presented with per orbital edema and neurological deficit of lower extre...
Chronic myelogenous leukaemia (CML) results from the Bcr-Abl oncoprotein, which has a constitutively activated Abl tyrosine kinase domain. Although most chronic phase CML patients treated with imatinib as first-line therapy maintain excellent durable responses, patients who have progressed to advanced-stage CML frequently fail to respond or lose their response to therapy owing to the emergence ...
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