BACKGROUND The aim of this work was to evaluate the efficacy of adding dexamethazone (DEX) (high dose, short course) to clomiphene citrate (CC) in CC-resistant polycystic ovary syndrome (PCOS) with normal dehydroepiandrosterone sulphate (DHEAS) in induction of ovulation. METHODS Eighty infertile women with CC-resistant PCOS were randomly assigned into two groups. Group I: Clomiphene citrate 1...

OBJECTIVE To evaluate the effect of clomiphene in men with hypogonadism and conventionally treated nonfunctioning pituitary adenomas (NFPA). PATIENTS AND METHODS Open label, single-arm, prospective trial. Nine hypogonadal men (testosterone < 300 ng/dL and low/normal LH) with previously treated NFPA. Clomiphene (50 mg/day orally) for 12 weeks. Testosterone, estradiol, LH, FSH, prolactin and er...

In a double-blind clinical trial, 114 subfertile men were given courses of clomiphene citrate (100 mg daily for three 10-day periods in successive months) and ofplacebo tablets of identical appearance. There were no consistent changes in sperm density. No serious adverse reactions to clomiphene were seen. Further studies are recommended on the efficacy of clomiphene in doses of 25 to 50 mg dail...

polycystic ovary syndrom (pcos) is characterized by infertility, oligomenorrhea, and hyperandrogenism. clomiphene citrate (cc), an antiestrogen, is first-line treatment for pcos, if cc fails to induce ovulation, laparascopic electrocautery of the ovaries is offered. in this prospective controlled study, 52 women with clomiphen-resistant pcos (group 1) and 46 women with regular menstrual cycles ...

BACKGROUND Subfertility due to anovulation is a common problem in women. First-line oral treatment is with anti-oestrogens, for example clomiphene citrate, but resistance (failure to ovulate) may be apparent with clomiphene. Alternative and adjunctive treatments have been developed such as tamoxifen, dexamethasone, and bromocriptine. OBJECTIVES To determine the relative effectiveness of anti-...

AIM Ovulation dysfunction is one of the most common causes of reproductive failure in infertile couples. The prevalence of this disorder in infertile women is about 30 to 40%. Polycystic ovary syndrome is a common disease that is closely related to ovulation dysfunction and 7% of women of childbearing age are afflicted with it. Ovulation induction is a way to treat infertility in PCOS which is ...

Introduction: Clomiphene, a selective estrogen receptor modulator (SERM), is drug which primarily used for the treatment of anovulatory infertility in female patients. Although as an off-label use, some authorities and physicians use this idiopathic oligoasthenospermia male Clomiphene has two isomers multiple metabolites, its cis isomer (Zuclomiphene) can be detected urine long eight months cas...