BACKGROUND Anxiety and depression are common mental health disorders that are responsible for considerable societal burden. There are no data on cost-efficacy and medication compliance related to the treatment of these disorders in rural India. MATERIALS AND METHODS All consenting adults (n = 455) diagnosed with generalized anxiety or (unipolar) depressive disorders in Suttur village, Karnata...

In the title compound, C(13)H(10)S(2)Te, the dibenzothio-phene moiety is almost planar, the maximum atomic deviation being 0.055 (5) Å. The two Te-C bonds are nearly perpen-dicular to each other with a C-Te-C bond angle of 93.0 (2)°. An inter-molecular C-H⋯π inter-action is present between the methyl-ene group and thio-phene ring.

the guiding rationale for the present study stemmed from the observations pertaining to a relatively high prevalence of obsessive compulsive disorder in iran and the importance of psychotropic drugs in the initial treatment and management of these cases. in this context, the aim of this investigation was to compare the relative efficacy of clomipramine, fluoxetine and tranylcypromine in the sym...

PURPOSE The aim of the study was to randomly compare clomipramine, used as a challenge-agent during head-up tilt test, with isoproterenol, used in the conventional test, in patients with vasovagal syndrome. SUBJECTS AND METHODS The serotonergic re-uptake inhibitor clomipramine was infused (5mg in 5min) at the start of head-up tilt test (Clom-HUT) in 126 patients (mean age 41+/-16 years) with ...

Little is known about the intracellular mechanisms involved in the pathophysiology of panic disorder (PD). Abnormalities in the cyclic AMP system have been described in several psychiatric disorders but there are no studies in panic patients. We evaluated not only the levels of platelet cyclic AMP, but also cyclic GMP and nitric oxide synthase (NOS) activity in patients with PD at baseline and ...

Human cytochromes P450 (P450s) play a major role in the biotransformation of drugs. The generated metabolites are important for pharmaceutical, medical, and biotechnological applications and can be used for derivatization or toxicological studies. The availability of human drug metabolites is restricted and alternative ways of production are requested. For this, microbial P450s turned out to be...

BACKGROUND This open trial was conducted to evaluate the effectiveness of intravenous clomipramine (CMI) in refractory obsessive-compulsive disorder (OCD). METHODS Thirty OCD poor responders to previous multiple trials of anti-obsessive medications were selected and admitted to the hospital. Severity of the illness and response to treatment were primarily assessed by the Yale-Brown Obsessive ...

trichotillomania refferes compulsive hair pulling that results in considerable hair loss.many medical and nonedical therapies have been applied for treatment of this disorder. the purpose of this study was to compare the efectiveness of clomipramine, hydroxyzine, and behavior therapy (habit reversal) in the treatment of trichottillomania. to achieve this 15 patients with trichotillomania were r...