Using a Taylor expansion to first order, a novel method was developed to calculate the uncertainty of drug concentration in pharmaceutical dosage forms. The method allows, in principle, calculation of the maximum potential error in drug concentration in a mixture composed of an infinite number of ingredients that are measured on multiple balances of variable sensitivity requirements.

Using the equation of continuity and equations for the atomic flux we develop the finitedifference-scheme program DIMES-C to calculate concentration profiles and layer thickness’ in multiphase binary systems after diffusion annealing. In this way we can calculate problems with arbitrary initial concentration distributions, concentration dependent interdiffusion coefficients, and general phase d...

! . p Figure 1: Calculation of Concentration Index Abstract: Concentration index filter is a kind of spatial filters of images, and its typical application is diagnosis from medical images. This paper presents a dedicated computing engine for concentration index filtering. Original algorithm is modified to extract full parallelism and data width is optimized for maximizing clock speed and minim...

Mathematical methods exist to determine the fractions of sex hormones bound to albumin, bound to sex hormone binding globulin (SHBG), or unbound, using total hormone concentration and SHBG concentration. We used data from eight prospective studies of postmenopausal women to assess the validity of these estimates for fractions of estradiol (E2) and to investigate the impact of using calculated v...

INTRODUCTION Cognitive neuropsychology focuses on the concepts of dissociation and double dissociation. The performance of number processing and calculation tasks by patients with acquired brain injury can be used to characterise the way in which the healthy cognitive system manipulates number symbols and quantities. The objective of this study is to determine the components of the numerical pr...

BACKGROUND The current methodology for sample size calculations for stepped-wedge cluster randomised trials (SW-CRTs) is based on the assumption of equal cluster sizes. However, as is often the case in cluster randomised trials (CRTs), the clusters in SW-CRTs are likely to vary in size, which in other designs of CRT leads to a reduction in power. The effect of an imbalance in cluster size on th...

There is a certain family of conformally invariant first order elliptic systems which include the Dirac operator as its first and simplest member. Their general definition is given and some of their basic properties are described. A special attention is paid to the Rarita-Schwinger operator, the second simplest operator in the row. Its basic properties are described in more details. In the last...

OBJECTIVES To assess quality of reporting of sample size calculation, ascertain accuracy of calculations, and determine the relevance of assumptions made when calculating sample size in randomised controlled trials. DESIGN Review. DATA SOURCES We searched MEDLINE for all primary reports of two arm parallel group randomised controlled trials of superiority with a single primary outcome publi...

As the portion of coupling capacitance increases in smaller process geometries, accurate coupled noise analysis is becoming more important in current design methodologies. We propose a method to determine whether aggressors can potentially switch simultaneously with the victim or not. The functional information is used to classify the aggressors. Our functional pruning algorithm inspects the co...