We conducted a case-control study to investigate the role of one single nucleotide polymorphism of MMP-9 rs3918242 in the development of coronary artery disease. The rs3918242 was amplified with 435-bp DNA fragments using polymerase chain reaction coupled with restriction fragment length polymorphism. When compared with control subjects, patients with coronary artery disease had higher systolic...

severe coronary artery disease often coexists with peripheral vascular atherosclerosis. the assessment of the supra-aortic circulation is, therefore, of clinical relevance. we herein describe a case of coronary artery disease treated with surgical revascularization using the internal mammary artery and thereafter the progressive atherosclerotic disease of the native coronary arteries as well as...

background: investigators frequently encounter continuous outcomes with plenty of values clumped at zero called semi-continuous outcomes. the gensini score, one of the most widely used scoring systems for expressing coronary angiographic results, is of this type. the aim of this study was to apply two statistical approaches based on the categorization and original scale of the gensini score to ...

objective: coronary artery disease (cad) is a multi-factorial and heterogenic disease with atherosclerosis plaques formation in internal wall of coronary artery. plaque formation results to limitation of the blood reaching to myocardium leading to appearance of some problems, such as ischemia, sudden thrombosis veins and myocardial infarction (mi). several environmental and genetic factors are ...

BACKGROUND Genetic variants of endothelial nitric oxide synthase (eNOS) could influence individual susceptibility to coronary artery disease. OBJECTIVE To assess whether Glu298-->Asp polymorphism of the eNOS gene is associated with the occurrence and severity of angiographically defined coronary artery disease in the Italian population. METHODS Polymerase chain reaction/restriction fragment...

Background: Genetic variants of endothelial nitric oxide synthase (eNOS) could influence individual susceptibility to coronary artery disease. Objective: To assess whether Glu→Asp polymorphism of the eNOS gene is associated with the occurrence and severity of angiographically defined coronary artery disease in the Italian population. Methods: Polymerase chain reaction/restriction fragment lengt...

BACKGROUND Rs619203 (Cys2229Ser) and rs529038 (Asp2213Asn) polymorphisms in the ROS1 gene have been studied in relation to myocardial infarction (MI) yielding inconsistent results. We investigated the role of ROS1 rs529038 polymorphism in coronary artery disease (CAD) in Greeks using a case-control study. METHODS Genotyping for rs529038 polymorphism was performed using a multiplex PCR techniq...

Abstract Background Coronary Artery Disease (CAD) is caused by the blockage of coronary arteries. it argued that there has an association between Interleukin-6 gene and occurrence atherosclerosis, artery disease, Due to short half-life high variability (IL-6), limited studies have been performed on serum levels interleukin-6 with disease. The aim this study investigate relationship IL-6 polymor...