[1] An atmospheric circulation model is used to show that a reduction in sea ice extent in the North Atlantic produces a climatic response consistent with abrupt changes in temperature and snow accumulation recorded in Greenland during the Dansgaard-Oeschger (D-O) events of the last glacial period. The model simulations exhibit warming that is especially pronounced in winter and an accumulation...

BACKGROUND Case-oriented small group discussions (COSGDs) can help students to correlate and integrate the basic science of dental materials into clinical application. We used COSGDs along with didactic lectures in dental material curriculum and hypothesized that case-oriented group discussions would be more effective than traditional lecture alone in terms of performance of students, student p...

OBJECTIVE To assess level of contamination of neckwear worn by gynaecologists and obstetricians during routine working week. DESIGN Multicentre randomised double blind crossover trial. Participants wore the same conventional ties for three days in one week and bow ties for the same period in second week. SETTING Two teaching and three district general hospitals in the midlands, Wales, and n...

The results of a multicentre, randomised, double-blind, placebo controlled, crossover trial of lamotrigine as add-on therapy in patients with partial seizures poorly controlled by established antiepileptic drugs (AEDs) are presented. The study consisted of two 12 week treatment periods each followed by a four week washout period. During the lamotrigine treatment phase, patients received 150 mg ...

Objectives. We wished to determine test re-test reliability and construct validity of the star-track test of manual dexterity. Design. Test re-test reliability was examined in a controlled study. Construct validity was tested in a blinded randomized crossover study. Setting. The study was performed at a university hospital in Denmark. Participants. A total of 11 subjects for test re-test and 20...

OBJECTIVE To evaluate the characteristics of the design, analysis, and reporting of crossover trials for inclusion in a meta-analysis of treatment for primary open-angle glaucoma and to provide empirical evidence to inform the development of tools to assess the validity of the results from crossover trials and reporting guidelines. METHODS We searched MEDLINE, EMBASE, and Cochrane's CENTRAL r...

In wheat (Triticum aestivum L.), the crossover (CO) frequency increases gradually from the centromeres to the telomeres. However, little is known about the factors affecting both the distribution and the intensity of recombination along this gradient. To investigate this, we studied in detail the pattern of CO along chromosome 3B of bread wheat. A dense reference genetic map comprising 102 mark...