introduction: the treatment of cutaneous leishmaniasis (cl) is based primarily on the use of pentavalent antimonials, which may lead to many side effects limiting their use. photodynamic therapy (pdt) is an alternative for the treatment of cl, and some xanthene dyes have the potential for use in pdt. methods: the xanthenes rose bengal b (rb) and its derivatives rose bengal methyl ester (rbmet),...

background: leishmaniasis is a protozoan disease cause by leishmania genus. anthroponotic and zoono­tic cutaneous leishmaniasis are endemic in iran. the aim of this study was to identify the causative agent of cutaneous leishmaniasis by mini-exon gene in five regions of khuzestan province, southwest of iran. methods: from 2007 to 2008 in this cross-sectional study, cutaneous samples were collec...

Leishmania amazonensis parasites are etiological agents of cutaneous leishmaniasis in the New World. BALB/c mice highly susceptible to L. challenge due their inability mount parasite-dependent IFN-γ-mediated responses. Here, we analyzed capacity a single administration LiΔHSP70-II genetically-modified attenuated infantum line preventing challenged with virulent parasites. In previous studies, t...

BACKGROUND An effective adaptive immune response requires activation of specific CD4 T cells. The capacity of B cells to activate CD4 T cells in human cutaneous leishmaniasis caused by Leishmania (Viannia) has not been evaluated. METHODS CD4 T cell activation by B cells of cutaneous leishmaniasis patients was evaluated by culture of PBMCs or purified B cells and CD4 T cells with Leishmania pa...

conclusions this is the first molecular report on parasite infection of both vector (p. papatas) and reservoir (t. indica) to l. major from this area. therefore, the population of both sandflies and rodents should be reduced using control methods. background leishmaniais which is one of the six most important tropical diseases in the world are in iran in 3 forms. cutaneous leishmaniasis (cl) is...

Leishmania infected of Lutzomyia spp. are rare in endemic areas. We tested the hypothesis that there is clustering of infected vectors by combining pinpoint capture with sensitive L. braziliensis kDNA minicircle specific PCR/dot blot in an endemic area in the State of Bahia. Thirty out of 335 samples (10 to 20 sand flies/sample; total of 4,027 female sand flies) were positive by PCR analysis an...

b a ckground: cutaneous leishmaniasis due to leishmania major is a serious and increasing problem affecting manyrural areas of 17 out of 31 provinces in iran. little is known about sand fly fauna and leishmaniases in eastern iran and no study has been carried out in sarbisheh county. the aim of this study was to determine sand flies composi- tion and probable leishmania infection to find the pr...

Leishmania RNA virus (LRV) has been shown to be a symbiotic component of Leishmania parasites in South America. Nested retro-transcription polymerase chain reaction was employed to investigate LRV1 presence in leishmaniasis lesions from Brazil. In endemic areas of Rio de Janeiro (RJ), no LRV1 infection was observed even with mucosal involvement. LRV1 was only detected in Leishmania (V.) guyanen...

INTRODUCTION Localized Cutaneous Leishmaniasis (LCL) and Mucosal Leishmaniasis (ML) are two extreme clinical forms of American Tegumentary Leishmaniasis that usually begin as solitary primary cutaneous lesions. Host and parasite factors that influence the progression of LCL to ML are not completely understood. In this manuscript, we compare the gene expression profiles of primary cutaneous lesi...