Regulator (ABCC7) Structure Cystic Fibrosis Transmembrane Conductance John F. Hunt, Chi Wang and Robert C. Ford Perspective The Cystic Fibrosis Gene: A Molecular Genetic Lap-Chee Tsui and Ruslan Dorfman Cystic Fibrosis Status of Fluid and Electrolyte Absorption in M.M. Reddy and M. Jackson Stutts Anion Permeation The CFTR Ion Channel: Gating, Regulation, and Tzyh-Chang Hwang and Kevin L. Kirk P...

  Cystic fibrosis (CF) is a life-limiting autosomal recessive disorder affecting principally respiratory and digestive system . It is caused by cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation. The aim of this study was to determine the extent of repeat numbers and the degree of heterozygosity for c.3499+200TA(7_56) and D7S523 located in intron 17b and 1 cM proximal to t...

Cystic fibrosis results from defects in the gene encoding a cyclic adenosine monophosphate-dependent chloride ion channel known as the cystic fibrosis transmembrane conductance regulator (CFTR). To create an animal model for cystic fibrosis, mice were generated from embryonic stem cells in which the CFTR gene was disrupted by gene targeting. Mice homozygous for the disrupted gene display many f...