Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The application of fluorescence in situ hybridization (FISH) based techniques such as comparative genomic hybridization (CGH) and spectral karyotyping (SKY) revealed that colorectal carcinomas are characterized by a specific pattern of chromosomal imbalances which sequentially accumulate during cancer progression. This r...

We performed prospective sequential cytogenetic studies in 76 patients with myelodysplastic syndromes (MDS) followed up to 82 months. Their karyotypes were followed routinely, regardless of clinical status. The incidence of evolutive karyotypes was similar in patients with a normal karyotype at referral and in patients with clonal abnormalities at diagnosis (24.5 and 26.1%, respectively). We di...

Cytogenetic effects of ciprofloxacin (500 to 2,000 mg daily) and ofloxacin (200 mg daily) were studied in lymphocytes from 31 patients treated for 1 to 10 weeks. Blood samples for cytogenetic analysis were taken before the start of treatment from all patients, after 1 week from 25 patients, and after 2, 4, 6, and 10 weeks from six patients. No chromosome-damaging effect could be demonstrated in...

introduction: robertsonian translocation is one of the major chromosomal rearrangements with a prevalence rate of 0.1% of the general population and 1% of the infertile population. in this report, we present a nonhomologous robertsonian translocation in a female patient with a history of repeated abortions. case presentation: a couple with the complaint of repeated abortions was admitted in the...

Chromosome aberrations and their impact on human health have been recognized for a long time. In the 1950s, in India, studies on induced chromosome aberrations in plants were initiated by Swaminathan and his students. I trace here the impact of these initial studies on further developments in this field. The studies which were started in plants have been extended to mammals (including human) an...

Background and Objectives: studying chromosomal changes for anemia patients of children age (3month-12years ) in the city kut diagnosing those abnormalities resulting from having Methods: The chromosomes Patients to were analyzed studied using cytogenetic analysis detect aberrations caused by after collecting blood samples Al-Karama Teaching Hospital as well clinics Kut.Results: Chromosomal all...

BACKGROUND AND OBJECTIVES The main prognostic factors in myelodysplastic syndromes (MDS) are chromosomal abnormalities, the proportion of blasts in bone marrow and number and degree of cytopenias. A consensus-defined International Prognostic Scoring System (IPSS) for predicting outcome and planning therapy in MDS has been developed, but its prognostic value in a large and independent series rem...

abstract background: acute meyloid leukemia (aml) in adults is known to be a heterogeneous disease with diverse chromosome abnormalities. some of these chromosome abnormalities are found with a high incidence in populations from specific geographical areas and ethnic societies. therefore, we studied the cytogenetic features of aml cases in contrasting societies of iran and india. methods: cytog...

Cytogenetic studies were carried out on a low-grade metastatic uterine leiomyosarcoma and on a large degenerating uterine leiomyoma. The leiomyosarcoma and leiomyoma were hyperdiploid and hypodiploid, respectively, and both tumors contained multiple consistent chromosome aberrations. In the patient with leiomyosarcoma, flow cytometric studies of proliferative foci from a previously resected ute...

Abstract Ionizing radiation is ubiquitous in the environment. Its source can be natural, such as radioactive materials present soil and cosmic rays, or artificial, fuel for nuclear power plants. Overexposure to ionizing may damage living tissue could cause severe health problems (i.e., mutations, sickness, cancer, death). Cytogenetic bio-dosimetry has great advantage take into account inter-ind...