the pathogenesis of equine grass sickness (egs) has not fully understood. a better understanding of the exact pathogenesis of diseases can help to make an accurate diagnosis. previous studies reported some pathological damage of neuronal cells in egs patients. in this study, primarily cytotoxicity of serum from three clinically egs-diagnosed horses on pc12 tet-off (pto) cells was assessed. subs...

Objective(s): The purpose of this study was to evaluate variations in yields, volatile composition and biological activities of essential oils (EOs) obtained from the aerial parts of Zhumeria majdae collected from five localities of the south of Iran. Materials and Methods: The EOs were analyzed using gas chromatography and gas chromatography-mass spectrometry techniques. The antioxidant activi...

Direct cytotoxicity and antibody dependent cell mediated cytotoxicity against Giardia lamblia trophozoites exhibited by splenic, intraepithelial and lamina propria lymphocyte populations isolated from G lamblia infected mice were studied. Different patterns of cytotoxicity were found. Intraepithelial lymphocytes showed a direct cytotoxic activity of 20.6 +/- 5.6% before infection. It was signif...

Antibacterial activity without cell cytotoxicity is conferred to common plastic materials by dispersion of amphiphilic cationic methacrylate-based block copolymers (0.5–2 wt%), while maintaining the mechanical properties materials.

Leishmaniasis is considered one of the most untreated tropical diseases in world. In this study, we investigated vitro leishmanicidal activity and cytotoxicity various isolated lichen substances, including atranorin (1), usnic acid (2), gyrophoric (3), salazinic (4), galbinic (5), parietin (6), some semi-synthetic imine derivatives (7, 8, 9) (10, 11, 12, 13). Imine condensation reactions with h...

Leaves and rhizome methanol extracts of Albertisia delagoensis tested positive against Plasmodium falciparum, with a very low cytotoxic activity in leaves against the Graham cell line.

AbstractFerulago angulata Boiss. known in Iran as Chavir, has some bioactive compounds having antioxidant activity. Because of its antioxidant activities, it sounded Chavir extract can be a good candidate for finding chemopreventive agents having inductive apoptosis properties on cancer cells. In this study, the cytotoxic effects and proapoptotic activities of Chavir’s leaf and flower extracts ...

Aims: Klebsiella pneumoniae can be defined as one of the virulent pathogens with a high level of antibiotic resistance. The goal of the presented work was to see if Capsicum annuum L. juice has antibacterial activity against K. pneumonia, a bacteria seen in respiratory tract infections. Materials & Methods: Fifty respiratory tract infections have been collected that include such bacterium’s r...

We demonstrated that the 3-substituted benzothiophene-1,1-dioxide class of compounds are effective inhibitors of Mycobacterium tuberculosis growth under aerobic conditions. We examined substitution at the C-3 position of the benzothiophene-1,1-dioxide series systematically to delineate structure-activity relationships influencing potency and cytotoxicity. Compounds were tested for inhibitory ac...