SimC7 is a polyketide ketoreductase involved in biosynthesis of the angucyclinone moiety of the gyrase inhibitor simocyclinone D8 (SD8). SimC7, which belongs to the short-chain dehydrogenase/reductase (SDR) superfamily, catalyzes reduction of the C-7 carbonyl of the angucyclinone, and the resulting hydroxyl is essential for antibiotic activity. SimC7 shares little sequence similarity with chara...

In the context of holographic QCD we analyze Sakai-Sugimoto’s chiral model at finite baryon density and zero temperature. The baryon number density is introduced through compact D4 wrapping S4 at the tip of D8-D8. Each baryon acts as a chiral point-like source distributed uniformly over R3, and leads a non-vanishing U(1)V potential on the brane. For fixed baryon charge density nB we analyze the...

Double-yolked (DY) and single-yolked (SY) duck eggs (n = 1318 for both) were candled and weighed on Days (d) 2, 8, 12, 15, 19, 22 and 25 of incubation and yolk/embryo position was recorded on d2, d8 and at post-mortem. From d8 only eggs with live fertile yolk(s) remained in the incubator. On d2, 99.39% of yolks in DY eggs were in the adjacent position and by d8 yolk positions changed to paralle...

OBJECTIVE The aim of our study was to investigate the association of HLA antigens and a non-HLA protein D8/17 with rheumatic heart disease and its pattern of cardiac involvement. METHODS This cross- sectional observational study included 35 children and 12 adult patients who have rheumatic heart disease and 35 healthy children and 12 healthy adult controls. After physical examination, all pat...

We present a holographic dual of four-dimensional, large Nc QCD with massless flavors. This model is constructed by placing Nf probe D8-branes into a D4 background, where supersymmetry is completely broken. The chiral symmetry breaking in QCD is manifested as a smooth interpolation of D8-D8 pairs in the supergravity background. The meson spectrum is examined by analyzing a five-dimensional Yang...