A comparison of clofazimine and dapsone in the management of untreated lepromatous leprosy showed no significant differences between the two drugs in terms of morphological and bacterial indices. The incidence of erythema nodosum leprosum was similar in the two groups. Since dapsone is cheaper than clofazimine it remains the drug of choice for the routine management of untreated lepromatous lep...

Dapsone is recommended as a second line therapy in immune thrombocytopenia (ITP), but is underused because of its potential side effects. The medical charts of 42 ITP patients treated with dapsone (100 mg/day) were retrospectively reviewed in order to assess its efficacy and safety in daily clinical practice. The overall response rate was 54.8% (n = 22, with a complete response in 38.1%) with a...

OBJECTIVE: The objective of this selective EBM review is to determine whether or not dapsone gel is safe and effective for the treatment of acne vulgaris. STUDY DESIGN: A review of three English language studies published in 2007. Includes two randomized, double-blind, controlled trials and one open label, noncomparative study. DATA SOURCES: Randomized, controlled trials comparing dapsone gel t...

AbstractDapsone is a bactericidal and bacteriostatic against Mycobacterium leprae, a causative agent of leprosy. Dapsone is also applied in a range of medical fields because of its anti-inflammatory and immunomodulatory effects. Dapsone hypersensitivity syndrome (DHS) is a rare yet serious adverse drug reaction (ADR) caused by dapsone involving multiple organs. We performed a systematic review ...

Abstract Background Erythema elevatum diutinum (EED) is a rare disease with unknown etiology, various presentations, broad spectrum of underlying conditions, and unified pathology. So, every case it merits further investigation for better understanding its causes pathophysiology. Case presentation I report the 32-year-old otherwise healthy man an 8-year history refractory solitary lesion on his...

Until the early 1 980s, dapsone monotherapy administered to known patients was used for control of leprosy. Dapsone was usually administered in a dosage of 100 mg daily for a minimum of 5 years to patients with paucibacillary (PB) leprosy, and for life to patients with multibacillary (MB) leprosy. Because it was a weakly bactericidal and slowly acting drug, dapsone monotherapy led to poor patie...