For the scientific community, the ability to fly mice under weightless conditions in space offers several advantages over the use of rats. These advantages include the option of testing a range of transgenic animals, the ability to increase the number of animals that can be flown, and reduced demands on shuttle resources (food, water, animal mass) and crew time (for water refill). Mice have bee...

To identify genetic expression of mandibular condylar cartilage during natural growth and under mechanical strain as a result of mandibular advancement. One hundred and forty four 35 days old female Sprague-Dawley rats were sacrificed on 8 different experimental days. Total RNA was extracted for oligonucleotide microarray gene chips containing 15,923 transcripts. Sixteen genes representing the ...

Background. Considering the increasing side effects of first-line treatment for acne vulgaris, metformin was developed to be an effective adjunct therapy, but its mechanism action is poorly defined. Recent evidence shows that gut microbiota a site action. The aim this study evaluate and in adjuvant vulgaris by regulating microbiota. Methods. First, untreated patients were randomly allocated int...

Objective: To study the effects of injection botox in masseter muscle on morphometric measurement underlying mandible and total body weight change Sprague Dawley rats.Study Design: Laboratory-based experimental study.
 Place Duration Study: Anatomy Department, Army Medical College, Rawalpindi, with collaboration Military Hospital, Rawalpindi National Institute Health (NIH), Islamabad, from...

Lifestyle associated disorders have always been a hazard for the advancement of chronic diseases. Therefore, use natural dietary sources is proved to be safe reducing occurrence and management Okra along with its various parts has used treatment several The present study was done examine ameliorating effect okra seed oil on hypercholesterolemic rats. Spargue Dawley Rats were randomly divided in...

objective(s): salvia miltiorrhiza (sm) is a popular and classic herb in traditional chineses medicines. the objective is to confirm the effects of aqueous extract of s. miltiorrhiza (esm) and its main ingredient on the promotion of orthodontic tooth movement and healing of periodontal ligament in rat. materials and methods: male sprague-dawley rats (n= 150) were divided into five groups: model ...

Recently a new rat model for type 2 diabetes the Zucker diabetic Sprague-Dawley (ZDSD/Pco) was created. In this study we sought to characterize the development of diabetic neuropathy in ZDSD rats using age-matched Sprague-Dawley rats as a control. Rats were examined at 34 weeks of age 12 weeks after the onset of hyperglycemia in ZDSD rats. At this time ZDSD rats were severely insulin resistant ...

Mitochondrial dysfunction is common in the brain with age. Prevention of mitochondrial at an early age may protect against neurodegeneration later life. Tocotrienol-rich fraction (TRF) has been reported to be neuroprotective old rats, but its effect remains unknown for middle-aged animals. This study aimed determine TRF on activities respiratory chain complexes hippocampus rats. Male Sprague Da...

Rats emit an alarm pheromone in threatening situations. Exposure of rats to this alarm pheromone induces defensive behaviors, such as head out behavior, and increases c-Fos expression in brain areas involved in the mediation of defensive behaviors. One of these brain areas is the anterior bed nucleus of the stria terminalis (aBNST). The goal of the present study was to investigate if pharmacolo...

It has long been known that the intracerebroventricular administration of ACTH1-24 increases the duration of grooming episodes and the frequency of yawning in rats. The objective of this study was to investigate in what way these episodes are prolonged and whether and to what extent genotype influences such effects. We compared the effect of increasing doses of intracerebroventricular injection...