نتایج جستجو برای: diazepine
تعداد نتایج: 232 فیلتر نتایج به سال:
in the current study, a magnetic inorganic–organic nanohybrid material (hpa/tpi-fe3o4) was produced and used as an efficient, highly recyclable and eco-friendly catalyst for the one-pot and multicomponent synthesis of 3,4-dihydroquinoxalin-2-amine, diazepine-tetrazole and benzodiazepine-2-carboxamide derivatives with high yields and in a short range of time (20–35 min). the nanohybrid catalyst ...
In this paper, has been described the synthesis of some novel tetrazolodiazepine derivatives starting from piperidin-4ones, with a view to test the novel compounds for various biological activities. The structures of the synthesized compounds have been established by IR, H and C NMR, mass and elemental analysis. Representative compounds have been characterized by COSY, HETCOR and DEPT 135 spect...
Spiro-N,N-ketal 5, consisting of a phthaloperine heterocyclic ring and a naphtha[1,8-ef][1,4]diazepine ring, was obtained along with spiro-N,N-ketal 2 via 2,2-condensation in the reaction of ninhydrin with naphthalene-1,8-diamine. Their molecular structures were elucidated by X-ray crystal structural analysis. Aside from these spiro compounds, the diazapleiadiene compound 3 formed by 1,2-conde...
CD spectra of a series of 5-aryl-7-chloro-l,3,4,5-tetrahydro2H-l,4-benzodiazepin-2-one derivatives having different substituents at positions 1, 3, 4, and 5 were studied. The absolute eonfiguration at C-5 of two homochiral analogues, 1 and 2, having enantiomorphous ring conformations was determined on the basis of chiroptical correlations and theoretical calculations. The latter have shown that...
The benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-one core was discovered as a novel ERK5 (also known as MAPK7 and BMK1) inhibitor scaffold, previously. Further structure-activity relationship studies of this scaffold led to the discovery of ERK5-IN-1 (26) as the most selective and potent ERK5 inhibitor reported to date. 26 potently inhibits ERK5 biochemically with an IC₅₀ of 0.162 ± 0.006 μM and in...
N-Cyclohexyl-2,4,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,5]diazepine-2-carboxamide (5) was synthesized using an efficient, highly recyclable and eco-friendly catalyst heteropolyacid/triethoxysilyl)propyl]isonicotinamide (HPA/TPI-Fe3O4 nanoparticles) in one-pot. The compound 5 was characterized by FT-IR,1H NMR, 13C NMR, mass spectra, and elemental analysis. The theoretical calculations on 5...
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