INTRODUCTION ES-62, a phosphorylcholine (PC)-containing immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, protects against nephritis in the MRL/Lpr mouse model of systemic lupus erythematosus (SLE). However, ES-62 is not suitable for development as a therapy and thus we have designed drug-like small molecule analogues (SMAs) based around its active PC-moiety. To provide p...

One of the main characteristics of HIV-1 infection is persistent systemic immune activation. This immune activation and dysregulation is characterized by a specific pattern of cytokine production, expression of membrane activation molecules on the cells of the immune system, and changes in the levels of several immune parameters in blood. Therefore, the aim of the present work was to evaluate t...

67 www.ijntr.org Abstract—Genome-wide association studies of psoriasis identified interleukin (IL)-12B and IL-23R as significantly associated loci with psoriasis, thus emphasizing to the important role of these genes in the pathogenesis of this disease and have influenced the development of medications that specifically target these key immunological players. Here we report an association study...

HCV is a major cause of liver disease worldwide. IL-12 plays an essential role in the balance of T helper 1 (Th1) differentiation versus a T helper 2 (Th2) driven response from its naïve precursor. Linkage disequilibrium measures the degree to which alleles at two loci are associated and the non-random associations between alleles at two loci. Haplotypes of the three IL-12B loci studied were de...

The decay of the 21.47-MeV stretched resonance in 13C, arising from p3/2→d5/2 nucleon excitation coupled to maximum spin, was investigated a (p,p′) experiment at 135 MeV proton bombarding energy, performed Cyclotron Centre Bronowice (CCB) IFJ PAN Krakow. First experimental information on and neutron branches this state obtained by using coincidence measurement protons inelastically scattered 13...

In this paper, dye removal ability of the surface modified nanoparticle SMN copper ferrite from single and quaternary systems was investigated. Acid Blue 92 AB92, Direct Green 6 DG6, Direct Red 23 DR23 and Direct Red 80 DR80 were used as model compounds. The effect of surfactant concentration, adsorbent dosage, dye concentration and pH on dye removal was evaluated. The adsorption isotherm and k...