Glycoconjugates [protein bound hexose, protein bound hexosamine, total sialic acid and fucose] play a pivotal role in neoplastic transformation if they are abnormally expressed. The protective effect of Enicostemma littorale leaves on cell surface abnormalities was analyzed by measuring the status of the above said glycoconjugates during 7,12dimethylbenz(a) anthracene (DMBA) induced hamster buc...

TG.AC transgenic mice harbor a v-Ha-ras transgene and retain two normal c-Ha-ras alÃ-elesand are susceptible to skin tumor formation by 12-O-tetradecanoylphorbol-13-acetate (TPA). To determine whether nor mal c-Ha-ras antagonizes the oncogenic potential of the v-Ha-ras transgene and/or whether additional non-Ha-ra.v 7,12-dimethylhenz(a (anthra cene (DMBA) initiation target genes exist in mouse ...

In the present investigation, we have examined the transcriptional regulation of adenomatous polyposis coli (APC) gene expression in the spontaneously immortalized human normal breast epithelial cell line, MCF10A, in response to carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) treatment. The APC mRNA levels and the APC gene's promoter (pAPCP) activity were increased in MCF10A cells after treatm...

Since the report by Yang et al. (11) that carcinogenic polynuclear aromatic hydrocarbons as a group bear steric resemblances to steroid hormones, there has been considerable interest in the effect of these compounds on the adrenals, gonads, and pituitary. Huggins and Morii (5) found that DMBA induced adrenal ne crosis and hemorrhage when fed to adult rats. There have been conflicting reports on...

The immature mammary glands of BALB/c female mice were treated with 7,12-dimethylbenz[a]anthracene (DMBA), 2 micrograms/ml, or 3-methylcholanthrene (10 micrograms/ml) for a 24-hr period at different times during the inital six days of lobuloalveolar growth in hormone-supplemented organ culture. Nodule-like alveolar lesions (NLAL) were detectable in 80% of the glands treated with DMBA (40% in 3-...

Objective: Some species of Astragalus are used for the treatment of various types of cancer. The present study was designed to evaluate the anticancer potential of Astragalus ovinus extract (AOE) against DMBA-induced breast carcinoma in rats. Materials and Methods: The anti-tumor and antioxidant effects of AOE were evaluated against DMBA...

Female rats of ten different inbred strains were tested for their susceptibility to 7, 12-dimethylbenz[a]anthracene (DMBA)-induced mammary adenocarcinogenesis. Five of these strains (OM, NSD, WF, LEWIS, BUFF) were demonstrated to be highly susceptible to DMBA exposure developing greater than 2 continuously growing, macroscopically detectable mammary adenocarcinomas/rat following gastric intubat...

Abstract. Rate coefficients for the reaction of NO3 radicals with a series aromatic aldehydes were measured in 7300 L simulation chamber at ambient temperature and pressure by relative absolute methods. The rate benzaldehyde (BA), ortho-tolualdehyde (O-TA), meta-tolualdehyde (M-TA), para-tolualdehyde (P-TA), 2,4-dimethyl (2,4-DMBA), 2,5-dimethyl (2,5-DMBA) 3,5-dimethyl (3,5-DMBA) k1= 2.6 ± 0.3,...

Methyl-hydroxylated metabolites of the potent carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA), namely, 7-hydroxymethyl-12-methylbenz[a]anthracene (7-OH-DMBA), 7-methyl-12-hydroxymethylbenz[a]anthracene (12-OH-DMBA) and 7,12-dihydroxymethylbenz[a]anthracene (7,12-diOH-DMBA), were examined as substrates for sulfotransferase bioactivation in different human tissue cytosols. Hepatic cytosols, whi...

TG.AC transgenic mice harbor a v-Ha-ras transgene and retain two normal c-Ha-ras alleles and are susceptible to skin tumor formation by 12-O-tetradecanoylphorbol-13-acetate (TPA). To determine whether normal c-Ha-ras antagonizes the oncogenic potential of the v-Ha-ras transgene and/or whether additional non-Ha-ras 7,12-dimethylbenz(a)anthracene (DMBA) initiation target genes exist in mouse skin...