Poor long-term adherence and persistence to drug therapy is universally recognized as one of the major clinical issues in the management of chronic diseases, and patients with renal diseases are also concerned by this important phenomenon. Chronic kidney disease (CKD) patients belong to the group of subjects with one of the highest burdens of daily pill intake with up to >20 pills per day depen...

INTRODUCTION Epilepsy is one of the neglected and highly stigmatised diseases, yet it is very common affecting about 70 million people worldwide. In Uganda, the estimated prevalence of epilepsy is 13% with about 156 new cases per 100,000 people per year. Adherence to antiepileptic drugs is crucial in achieving seizure control yet in Uganda; there is lack of information on adherence to antiepile...

BACKGROUND Among people living with HIV/AIDS, illicit drug use is a risk for sub-optimal treatment outcomes. However, few studies have examined the relative contributions of different patterns of drug use on adherence to antiretroviral therapy (ART). We sought to estimate the effect of different types of illicit drug use on adherence in a setting of universal free HIV/AIDS treatment and care. ...

Response to Maximizing Treatment Adherence: Physician–Patient Partnerships vs Procedures We thank Bensadon1 for the comments on our review article on drug adherence in resistant hypertension.2 The author is concerned by the fact that we ignored the critical role of physicians in supporting drug adherence and that we did not discuss the potential benefits of behavioral interventions in the manag...

The adherence of patients to therapy is a crucial factor for successful HIV anti-retroviral therapy. Imperfect adherence may lead to treatment failure, which can cause the emergence of resistance within viral populations. We have developed a stochastic model that incorporates compartments of latently infected cells and virus genotypes with different susceptibilities to three simultaneously used...

Adherence to drug therapy is crucial for drug efficacy and prevention of drug resistance. A crosssectional study of 53 patients (40 receiving free medication and 13 on self purchased drugs) attending the Center for Special Studies clinic in Sagamu, Nigeria between September 1 and November 30, 2003 was carried out to determine the level of adherence and the factors associated with non adherence....

OBJECTIVES Drug interactions, poor adherence to medication and high-risk sexual behaviour may occur in individuals with HIV using recreational drugs. Thus, we aimed to assess the prevalence of recreational drugs use and to explore its clinical impact in HIV patients on treatment. METHODS Observational, cross sectional, study conducted in a 700 bed university hospital, Barcelona, Spain. A tota...

In the era of antiretroviral therapy (ART) as prevention for transmission of HIV as well as treatment for HIV-positive individuals irrespective of CD4 cell counts, the importance of adherence has grown. Although adherence is not the only determinant of treatment success, it is one of the only modifiable risk factors. Treatment failure reduces future treatment options and therefore long-term cli...

BACKGROUND Patients with depression are often nonadherent to therapy for depression and chronic comorbid conditions. METHODS To determine whether improved antidepressant medication adherence is associated with an increased likelihood of chronic comorbid disease medication adherence and reduced medical costs, we conducted a retrospective study of patients initiating antidepressant drug therapy...