Objective: This study aimed to investigate the effect of psychotherapy based on quality of life improvement (QoLI) on emotion regulation and the prevention of relapse in addicts under methadone maintenance therapy (MMT). Methods: This research is a semi-experimental pretest-posttest study with a control group. Eight sessions of psychotherapy training based on QoLI were implement...

multidrug resistance (mdr) is a complex phenomenon in which many different genes regulating drug transport, cellular repair, detoxification and drug metabolism are involved. nevertheless, in most drug resistant cell lines and cancer patients up-regulation of abc-transporter genes such as mdr associated protein (mrp1) gene could be at the basis of the drug resistance phenotype. we aimed to decre...

The drug metabolism is a biochemical process on modification of pharmaceutical substances through specialized enzymatic systems. Changes in the expression of drug-metabolizing enzyme genes can affect drug metabolism. Recently, epigenetic regulation of drug-metabolizing enzyme genes has emerged as an important mechanism. Epigenetic regulation refers to heritable factors of genomic modifications ...