In order to understand genetic polymorphisms among Entamoeba histolytica strains in a limited geographic area and among restricted social populations, we studied nucleotide polymorphism in DNA regions that do not encode proteins (locus 1-2 and locus 5-6) and in genes coding for chitinase and for serine-rich E. histolytica protein. Thirty E. histolytica isolates from domestically infected Japane...

Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. The genetics of POAG are complex, and population-specific effects have been reported. Although many polymorphisms associated with POAG risk have been reported, few studies have analyzed their additive effects. We investigated, in a southern European Mediterranean population, the association between relevant POAG polym...

Significant reductions in prostate cancer incidence and mortality were observed in men randomized to receive 50 mg supplemental vitamin E (alpha-tocopherol) per day in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. We hypothesized that variation in key vitamin E transport genes might directly affect prostate cancer risk or modify the effects of vitamin E supplementation. As...

Objective(s): Previous studies have reached different conclusions regarding an association between apolipoprotein E (APOE) polymorphisms and depression. This meta-analysis was designed to clarify these controversies. Materials and Methods: Literatures were identified reviewing the national and international databases. The eligible articles for meta-analysis were determined by quality assessment...

background: half of the cases of vision loss in people under 60 years of age have been attributed to age-related macular degeneration (amd). this is a multifactorial disease with late onset. it has been demonstrated that many different genetic loci are implicated in the risk of developing amd in different populations. in the current study, we investigated the association of high-temperature ‎re...

background: breast cancer is the most common malignancy among women. it is estimated that 1 in 10 women worldwide is affected by breast cancer during their lifetime. in 5 to 10% of breast cancer patients, the disease results from a hereditary predisposition, which can be attributable to mutations in either of two tumor suppressor genes, brca1 and brca2 to a large extent. brca2 6174delt mutation...

background: during recent years, infection of acinetobacter baumanii showed a rapid growth in hospitals and community. toll-like receptors (tlrs) are the most important pattern recognition receptors, which play a critical role during recognizing invading pathogens by the natural immune system. our objective was to determine the associations of tlrs polymorphisms with the susceptibility to a. ba...

PURPOSE To study the association of selected polymorphism in genes related to vitamin E, vitamin C, and glutathione peroxidase with these biomarkers and primary open-angle glaucoma (POAG) risk. METHODS A case-control study matched for age, sex, and bodyweight was undertaken. Two hundred fifty POAG cases and 250 controls were recruited from a Mediterranean population. Plasma concentrations of ...

Abstract There was a difference in the genetic profiles of CYP21 genotype, it showed three polymorphisms: 250/240, 260/251 and 270/261 bp, their distribution ratios were 51.72, 29.31, 18.96%, respectively. The percentages highly significant differences (P≤0.01), total studied alleles 116. study that there no production milk its components between polymorphisms, as well rate flow. (P≤0.05) diffe...

BACKGROUND Atopy and allergic phenotypes are biologically characterized by an imbalanced T helper cell response skewed towards a type 2 (TH2) immune response associated with elevated serum immunoglobulin E (IgE) levels. Polymorphisms in cytokine genes might modulate regulation of the TH1/TH2 balance. We thus aimed at reproducing our previous findings from a European study population on the asso...