BACKGROUND Non-invasive diagnosis and risk stratification of coronary artery disease are important for the selection and optimization of therapeutic interventions in diabetic patients, which may improve survival. The aim of this study was to determine the incremental value of contrast-enhanced dobutamine stress echocardiography (CE-DSE) for risk stratification. METHODS AND RESULTS CE-DSE was ...

BACKGROUND The combination of systemic arterial hypertension and diabetes mellitus (DM) induces greater cardiac remodeling than either condition alone. However, this association has been poorly addressed in senescent rats. Therefore, this study aimed to analyze the influence of streptozotocin-induced DM on ventricular remodeling and oxidative stress in aged spontaneously hypertensive rats (SHR)...

BACKGROUND The incretin hormone, glucagon-like peptide-1, promotes myocardial glucose uptake and may improve myocardial tolerance to ischemia. Endogenous glucagon-like peptide-1 (7-36) is augmented by pharmacological inhibition of dipeptidyl peptidase-4. We investigated whether chronic dipeptidyl peptidase-4 inhibition by sitagliptin protected against ischemic left ventricular dysfunction durin...

Aim: To find the frequency of left ventricular diastolic dysfunction in patients with diabetes on Doppler echocardiography by measuring their early to late diastolic mitral inflow velocity (E/A ratio) and deceleration time (DT) on Pulse Wave (PW) Doppler and E’ velocity on tissue volume imaging (TVI). Methods: A sample of 97 asymptomatic patients, male and female, was taken from Department of C...

This review focuses on transthoracic Doppler echocardiography as noninvasive method used to assess coronary flow reserve (CFR) in a wide spectrum of clinical settings. Transthoracic Doppler echocardiography is rapidly gaining appreciation as popular tool to measure CFR both in stenosed and normal epicardial coronary arteries (predominantly in left anterior descending coronary artery). Post-sten...

stress-induced cardiomyopathy or takotsubo cardiomyopathy is a recently increasing diagnosed disease manifested by transient apical or mid left ventricular dilation and dysfunction. this sign is similar to acute myocardial infarction but without significant coronary artery stenosis. there are important and essential differences between takotsubo cardiomyopathy and acute myocardial infarction in...

Clinical and experimental studies indicate an association between diabetes mellitus and myocardial dysfunction, eventually leading to congestive heart failure irrespective of the presence or absence of arterial hypertension and coronary artery disease. However, myocardial dysfunction due to diabetes mellitus, referred to as “diabetic cardiomyopathy,” is not generally accepted as a distinct clin...

  Introduction: Although left ventricular(LV) function parameters measured by gated myocardial perfusion SPECT (GSPECT) have been validated, experimental data have revealed that the calculated the LV function parameters using GSPECT are affected by patient populations as well as particular acquisition and processing conditions. We tried to determine the normal values ...

background: cardiac dysfunction due to chronic anemia and hemosiderosis are the major causes of death among patients with thalassemia intermedia. this study was performed to compare the cardiac function in thalassemia intermedia patients with normal subjects by means of echocardiography. materials and methods: this was a case-control study performed on 22 patients affected by thalassemia interm...