BACKGROUND Methotrexate is the most commonly used disease modifying antirheumatic drug in the treatment of juvenile idiopathic arthritis and can be effective in controlling disease in many patients. MAIN BODY A significant proportion of patients experience nausea and vomiting induced by methotrexate therapy, which can lead to decreased quality of life and discontinuation of treatment with met...

Carapichea ipecacuanha produces various emetine-type alkaloids, known as ipecac alkaloids, which have long been used as expectorants, emetics, and amebicides. In this study, we isolated an O-methyltransferase cDNA from this medicinal plant. The encoded protein (CiOMT1) showed 98% sequence identity to IpeOMT2, which catalyzes the 7'-O-methylation of 7'-O-demethylcephaeline to form cephaeline at ...

of cure and also had recourse very often to fasting and to other remedies, such as emetics, purgatives and diuretics. Some herbs found in the desert and still known to the Arabs Were used for medicinal purposes. The Egyptians thought themselves the first to invent the cure of diseases' Papyri have been found which contain many medical prescriptions for a variety of diseases, viz., those of the ...

Substance abuse is prevalent in adolescent street children, and death is reported as secondary to aspiration, accidental trauma, asphyxia, cardiac arrhythmia, anoxia, vagal inhibition and respiratory depression. In this study, we examined electrocardiographic and echocardiographic findings from 53 street male adolescents, comparing our findings to those obtained from 61 controls in the same age...

Acupuncture and related techniques are increasingly practised in anaesthesia. This paper reviews the current evidence and applicability of acupuncture and related techniques for anaesthetic procedures and postoperative nausea and vomiting. Recent evidence suggests that manual acupuncture is effective for reducing preoperative anxiety and for postoperative pain relief. Current available data do ...

Most plastic ingestion studies rely on dissection of dead birds, which are found opportunistically, and may be biased. We used Leach's Storm-petrels (Oceanodroma leucorhoa) in Newfoundland to study the effect of dose volume, and the efficacy of emesis using syrup of ipecac as an emetic. Ipecac is a safe method of non-lethally sampling stomach contents, and recovered all ingested plastic. Almost...

The hedonic properties of lysergic acid diethylamide (LSD) were assessed using the place conditioning, taste reactivity, and taste avoidance tests. LSD produced a conditioned place preference, but only at the highest dose tested (0.2 mg/kg). A single preexposure to the conditioning chamber (latent inhibition) prevented the establishment of a place preference. When paired with sucrose, doses of ...

This alkaloid has been known for some time as a powerful, prompt and safe emetic ; and the great facility with which it can be administered hypodermically renders it an extremely useful drug in cases of poisoning or where rapid erne sis is imperatively required. But it is with another and more important object that we have ventured to bring this medicine to more general notice, viz., its power ...

A mycotoxin responsible for vomiting in swine has been isolated from Fusarium-contaminated field corn. The compound was tentatively identified as a trichothecene, 3,7,15-trihydroxy-12,13-epoxy-trichothe-9-en-8-one, and has been given the trivial name vomitoxin.