BACKGROUND Emulsifiers have a significant role in the emulsion polymerization by reducing the interfacial tension thus increasing the stability of colloidal dispersions of polymer nanostructures. This study evaluates the impact of four emulsifiers on the characteristics of polyurethane hollow structures used as drug delivery system. RESULTS Polyurethane (PU) structures with high stability and...

the present work was aimed to design and develop self-nanoemulsifying drug delivery systems (snedds) with the objective to overcome the problems associated with the delivery of talinolol, a hydrophobic and poorly bioavailable drugs having ph dependant solubility. the solubility of talinolol in various oils, surfactants, cosurfactants and aqueous phases were determined to identify and select the...

Ketoconazole is an imidazole antifungal drug belonging to the class II of Biopharmaceutic Classification System. Maintenance of gastric acidity is essential for adequate dissolution and absorption of ketoconazole. Concurrent administration of antacid and antiulcer preparations decreases the oral absorption of ketoconazole often causing therapeutic failure. The aim of this study was to evaluate ...

Lipid-based formulations encompass a diverse group of formulations with very different physical appearance, ranging from simple triglyceride vehicles to more sophisticated formulations such as self-emulsifying drug delivery systems (SEDDS). Lipid-based drug delivery systems may contain a broad range of oils, surfactants, and co-solvents. They represent one of the most popular approaches to over...

The key role of antioxidants in treating and preventing many systemic and topical diseases is well recognized. One of the most potent antioxidants available for pharmaceutical and cosmetic use is Idebenone (IDE), a synthetic analogue of Coenzyme Q10. Unfortunately, IDE's unfavorable physicochemical properties such as poor water solubility and high lipophilicity impair its bioavailability after ...

Self emulsifying is a topic of current interest for overcoming the formulation difficulties of drugs with poor aqueous solubility. SEDDS are isotropic mixture of oil, surfactant and co-surfactant with a unique ability to form fine oil-inwater (o/w) emulsions or micro emulsions upon mild agitation in the gastrointestinal tract which present the drug in a solubilized form, and the small size of f...

Self nano emulsifying drug delivery systems (SNEDDs) gained much attention in the last decades since, such considered one of most favorable and efficient approaches to enhance solubility, increase absorption hence, its oral bioavailability poorly water soluble (lipophilic) moieties. Owing their unique properties advantages over other conventional dosage forms, many literatures investigate chang...

the objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (dds) for metoprolol tartarate (mt) as tablet and capsule. pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery ...

Skin is an important organ of the body due to offering an accessible and convenient site for drug administration. One of the disadvantages of transdermal drug delivery is the low penetration rate of drugs through the skin. Over the past decades, nanoparticles have been used as drug delivery systems to increase therapeutic effects or reduce toxicity. Encapsulation of drugs in nanoparticulate ves...