Background: ES is an ultra-rare sarcoma characterized by the absence of INI1/SMARCB1. The activation EZH2, consequent to loss INI1, has been identified as relevant for therapeutic targeting. We exploited patient-.derived xenograft (PDX) models and paired cell lines test activity tazemetostat plus doxorubicin identify modifiers tumor response resistance. Material methods: established two PDXs in...

Even if we limit ourselves to models of con dentiality, there are two related, but distinct, senses of the term security model in the computer security literature [McL90b]. In the more limited use of the term, a security model speci es a particular mechanism for enforcing con dentiality, called access control, which was brought over into computer security from the world of documents and safes. ...

In a fuzzy metric space (X;M; *), where * is a continuous t-norm,a locally fuzzy contraction mapping is de ned. It is proved that any locally fuzzy contraction mapping is a global fuzzy contractive. Also, if f satis es the locally fuzzy contractivity condition then it satis es the global fuzzy contrac-tivity condition.    

Background: Different immunological methods are used for the serodiagnosis of Fasciola hepatica infections, however, they have limited specificity and/or sensitivity.Objective: To improve the specificity of ELISA using a partially modified method for preparation of excretory-secretory (ES) antigens.Methods: Studied groups were as follows: 75 patients with parasitological evidence of fascioliasi...

Density functional theory is applied to the computation of the adsorption energy (DEads) for a series of molecules on c-Al2O3. Three different cluster models are used to represent the c-Al2O3 surface. The molecules of interest all contain a phosphonyl (P@O) functional group and adsorb via formation of a donor bond between the O atom and a threefold-coordinated tetrahedral Al [Al(Td)] surface si...

This paper deals with Expert Systems (ES) development as the final product of a Software Product Line. (SPL). We take into account software variability management in the ES domain. Two kinds of variability emerge: variability in the behavior as well as in the structure of such systems. Experts' knowledge is captured using domain conceptual models in order to manage the variability and functiona...

Genotype-by-environment interaction (GxE) has been widely reported in dairy cattle. One way to analyze GxE is to apply reaction norm models. The first derivative of a reaction norm is the environmental sensitivity (ES). In the present study we conducted a large-scale, genome-wide association analysis to identify single-nucleotide polymorphisms (SNPs) that affect general production (GP) and ES o...

The science of ecosystem service (ES) mapping has become increasingly sophisticated over the past 20 years, and examples of successfully integrating ES into management decisions at national and sub-national scales have begun to emerge. However, increasing model sophistication and accuracy-and therefore complexity-may trade-off with ease of use and applicability to real-world decision-making con...

OBJECTIVE To identify geographic and climatic risk factors associated with exfoliation syndrome (ES). METHODS A retrospective study of 626 901 eye care recipients, dating from 2001 to 2007 from 47 US states in a managed care network. Incident ES cases-patients (N = 3367) were identified by using billing codes. We assessed the risk of ES by geographic latitude tier in the continental United St...