conclusions a significant number of patients would benefit from surgical therapy to treat their gerd symptoms, but some incorrect beliefs still misguide the indications for the surgical procedure. results our review showed that: (a) the mortality rate of the surgical procedure is negligible and ppi therapy is also accompanied with mortality; (b) there is a 5% chance of severe dysphagia after an...

The literature review focuses on the current understanding of visceral hypersensitivity mechanisms in esophagus. Mechanisms peripheral and central sensitization their relation to heartburn symptoms are covered detail. Diagnostic criteria algorithms for non-erosive reflux disease, functional heartburn, esophagus based pH-impedance testing high-resolution esophageal manometry data presented.

OBJECTIVE To assess the esophageal function profile and the prevalence of gastro-esophageal reflux (GER) in lung transplant candidates. METHODS From July of 2005 to November of 2006, a prospective study was conducted involving 55 candidates for lung transplantation at the Santa Casa de Misericórdia Hospital in Porto Alegre, Brazil. Prior to transplantation, patients underwent outpatient stati...

CONTEXT Gastroesophageal reflux disease (GERD) is common in patients with respiratory disorders and interstitial lung fibrosis from diverse disease processes. However, a cause-effect relationship has not been well demonstrated. It is hypothesized that there might be more than a coincidental association between GERD and interstitial lung damage. There is still confusion about the diagnostic step...

Background/Aims The post-reflux swallow-induced peristaltic wave (PSPW) index and esophageal baseline impedance (BI) are novel impedance parameters used to evaluate esophageal chemical clearance and mucosal integrity. However, their relationship with reflux symptoms is not known. We aim to evaluate the correlations of PSPW index and esophageal BI with gastroesophageal reflux disease (GERD) symp...

OBJECTIVE To report the prevalence of esophagitis in patients with pH-documented laryngopharyngeal reflux. STUDY DESIGN Prospective study of 58 consecutive patients with documented laryngopharyngeal reflux, all of whom underwent transnasal esophagoscopy as part of their reflux evaluations. METHODS All patients with a diagnosis of laryngopharyngeal reflux confirmed by abnormal pharyngeal pH ...

BACKGROUND Gastroesophageal reflux disease (GERD) is comprised of a spectrum of related disorders, including hiatal hernia, reflux disease with its associated symptoms, erosive esophagitis, peptic stricture, Barrett's esophagus, and esophageal adenocarcinoma. Besides multiple pathophysiological associations among these disorders, they are also characterized by their comorbid occurrence in ident...

Gastroesophageal reflux disease (GERD) is the main etiological factor behind the recent rapid increase in the incidence of esophageal adenocarcinoma. During reflux, esophageal cells are exposed to bile at low pH resulting in cellular damage and inflammation, which are known to facilitate cancer development. In this study, we investigated the regulation of p73 isoform, ΔNp73α, in the reflux cond...

Gastroesophageal reflux disease (GERD) is one of the most common esophageal diseases in developed countries. It is widely believed that GERD symptoms are caused by acid refluxate within the esophagus, so ambulatory 24 hour pH-monitoring became the gold standard in detecting gastroesophageal reflux. Traditional ambulatory pH monitoring is unable to detect a gastroesophageal reflux with pH >4. Th...