according to the definition by the national institutes of health of usa, a biological marker (biomarker) is a characteristic that is objectively measured and evaluated, as an indicator of normal biological processes, pathogenic processes or pharmacological responses, to a therapeutic agent. several studies have reported that a decreased regulating gene expression of biotinidase (btd) is associa...

Digital forensics is a science related to the analysis of digital devices in order to find evidences of a crime. However, the overwhelming amount of data required to be handled, caused by the increase of storage capacity of hard disks, make examiners’ work harder and sometimes impossible to succeed in a reasonable time. For this reason, methods that can reduce the time needed in an investigatio...

To assess the effects of pre-analytical handling (storage time and temperature) on selected hematological parameters, whole blood samples were collected in EDTA coated tubes from each of 30 clinically normal male adult beagle dogs. Each sample was separated in 2 aliquots, of which one was stored in ambient temperature (25 ˚C) and the other one was refrigerated (2 to 4 ˚C). Complete blood counts...

Empirical evidences suggest that both common and rare variants contribute to complex disease etiology. Although the effects of common variants have been thoroughly assessed in recent genome-wide association studies (GWAS), our knowledge of the impact of rare variants on complex diseases remains limited. A number of methods have been proposed to test for rare variant association in sequencing-ba...