نتایج جستجو برای: exencephaly
تعداد نتایج: 186 فیلتر نتایج به سال:
BACKGROUND A precise temporal and spatial regulation of gene expression is necessary to achieve neural tube closure. Med12, a subunit of the mediator complex, can bind transcription factors and modulate expression of their target genes. Med12 is essential during early mouse development and is important for neural tube closure. METHODS We have made use of a mouse line carrying a conditional nu...
BACKGROUND Suboptimal maternal folate status is considered a risk factor for neural tube defects (NTDs). However, the relationship between dietary folate status and risk of NTDs appears complex, as experimentally induced folate deficiency is insufficient to cause NTDs in nonmutant mice. In contrast, folate deficiency can exacerbate the effect of an NTD-causing mutation, as in splotch mice. The ...
Background and Objective: Fennel seeds, which are incorporated in many drugs and drinks, act as agents to increase appetite, energy, calmness, and milk secretion. This study was set to investigate the effects of fennel seeds on pregnancy. Materials and Methods: Four doses of 50,100,200,400 mg / kg of fennel seeds were prepared. Then, 4 groups of 7 BALB/ C female mice weighting 21 to 25 grams...
Although neural tube defects (NTDs) are common in humans, little is known about their multifactorial genetic causes. While most mouse models involve NTDs caused by a single mutated gene, we have previously described a multigenic system involving susceptibility to NTDs. In mice with a mutation in Cecr2, the cranial NTD exencephaly shows strain-specific differences in penetrance, with 74% penetra...
Out of a total of 21 exencephalic p53-deficient embryonic and newborn mice, 6 (28.6%) possessed fused maxillary incisor teeth. On histological analysis of the 5 examples seen on day 19.5 of gestation and newborn mice, 3 varieties were observed: an example of 'simple' fusion, 3 examples of simple fusion each of which contained a 'dens in dente' ('tooth within a tooth'), and a single example in w...
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