نتایج جستجو برای: experimental autoimmue encephalomyelitis model

تعداد نتایج: 2637440  

Journal: :Annals of neurology 2005
Subramaniam Sriram Israel Steiner

Despite many years of intensive research, multiple sclerosis (MS) defies understanding and treatment remains suboptimal. The prevailing hypothesis is that MS is immune mediated and that experimental allergic encephalomyelitis (EAE) is a suitable model to elucidate pathogenesis and devise therapy. This review examines critically the validity that EAE is an adequate and useful animal model of MS ...

Journal: :The Journal of clinical investigation 2003
Nader Najafian Tanuja Chitnis Alan D Salama Bing Zhu Christina Benou Xueli Yuan Michael R Clarkson Mohamed H Sayegh Samia J Khoury

CD8+ T cell depletion renders CD28-deficient mice susceptible to experimental autoimmune encephalomyelitis (EAE). In addition, CD8-/-CD28-/- double-knockout mice are susceptible to EAE. These findings suggest a role for CD8+ T cells in the resistance of CD28-deficient mice to disease. Adoptive transfer of CD8+CD28- T cells into CD8-/- mice results in significant suppression of disease, while CD...

2004
Kalipada Pahan Subhajit Dasgupta Malabendu Jana You Zhou Yiu K. Fung Sankar Ghosh

2016
Yanhong Sun Xiaoyan Wan Juan Ouyang Renfeng Xie Xueping Wang Peisong Chen

Objective. Prenatal glucocorticoids (GC) can induce long term effects on offspring health. However, reports and related studies regarding the prolonged effects of prenatal GC on the development of autoimmunity are limited. Here, we aimed to explore the immunological effects of dexamethasone (DEX) exposure on young adults and whether glucocorticoid receptor (GR) is involved in this process. Meth...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Yanping Wang Steven J Marling Jinge G Zhu Kyle S Severson Hector F DeLuca

The development of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, has been studied in mice that were (i) vitamin D-deficient, (ii) minus the vitamin D receptor, (iii) minus a vitamin D 25-hydroxylase, and (iv) minus the vitamin D 25-hydroxyvitamin D-1α-hydroxylase. EAE development was markedly suppressed in mice lacking the vitamin D receptor and partially suppr...

2012
Harald F. Langer Eun Young Choi Hong Zhou Rebecca Schleicher Kyoung-Jin Chung Zhongshu Tang Kerstin Göbel Khalil Bdeir Antonios Chatzigeorgiou Connie Wong Sumeena Bhatia Michael J. Kruhlak John W. Rose James B. Burns Kenneth E. Hill Hongchang Qu Yongqing Zhang Elin Lehrmann Kevin G. Becker Yunmei Wang Daniel I. Simon Bernhard Nieswandt John D. Lambris Xuri Li Sven G. Meuth Paul Kubes Triantafyllos Chavakis

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Jayagopala Reddy Zsolt Illes Xingmin Zhang Jeffrey Encinas Jason Pyrdol Lindsay Nicholson Raymond A Sobel Kai W Wucherpfennig Vijay K Kuchroo

SJL mice are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) peptide 139-151, whereas H-2 congenic B10.S mice are resistant. Immunodominance and susceptibility to EAE are associated with a high precursor frequency of PLP 139-151-specific T cells in the naive repertoire of SJL mice. To understand the mechanism of EAE resistance ...

Journal: :Journal of immunology 2005
Mandy J McGeachy Leigh A Stephens Stephen M Anderton

Immune regulation of autoimmune disease can function at two sites: at the secondary lymphoid organs or in the target organ itself. In this study, we investigated the natural resolution of autoimmune pathology within the CNS using murine experimental autoimmune encephalomyelitis (EAE). Recovery correlates with the accumulation of IL-10-producing CD4+CD25+ T cells within the CNS. These CD4+CD25+ ...

2012
Shane E. Russell Anne C. Moore Padraic G. Fallon Patrick T. Walsh

A strong association exists between mutations at the IL2 receptor alpha chain (CD25) gene locus and susceptibility to a number of T cell driven autoimmune diseases. Interestingly, the presence of certain CD25 susceptibility alleles has been correlated with significantly increased levels of the soluble form of CD25 (sCD25) in the serum of patients. However, the functional consequences, if any, o...

Journal: :Trends in immunology 2005
Lawrence Steinman Scott S Zamvil

Experimental autoimmune encephalomyelitis (EAE) is a useful model for aiding the development of new treatments for MS. All therapies approved for MS ameliorate EAE. Two approved medications, glatiramer acetate and Natalizumab, were developed directly from studies in EAE. Several trials are ongoing in MS after success in EAE, including altered peptide ligands of myelin, DNA vaccines and statins....

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