Estradiol, a major form of estrogen, plays crucial role in various aspects brain function, including neuronal health, synaptic plasticity, and cognitive processes. Therefore, it is interest to investigate the histopathological changes rat following estradiol treatment unilateral bilateral ovariectomized rats, commonly used method induce estrogen deficiency study consequences hormonal changes. T...

Albino and hooded (or piebald) rats are one of the most frequently used laboratory animals for the past 150 years. Despite this fact, the origin of the albino mutation as well as the genetic basis of the hooded phenotype remained unclear. Recently, the albino mutation has been identified as the Arg299His missense mutation in the Tyrosinase gene and the hooded (H) locus has been mapped to the ∼4...

Propylthiouracil (PTU) is often used to produce experimental hypothyroidism. In general, PTU generates hepatotoxicity, albeit with dissimilar incidence rates of hepatotoxicity. This study examined the hepatoprotective effects Saussurea lappa root ethanol extract on experimentally induced hepatotoxicity in female rats. For this study, 25 adult albino rats were placed into five equal groups: cont...

Objective: the objective was to evaluate the effect of petroleum ether, ethanol, and water extract of Bauhinia racemosa in female albino rats. Materials and Methods: Plant extracts were tested for their estrogenic activity using ovariectomized method at two dose level: 200 mg/kg and 400 mg/kg, respectively. Further, plant extracts and standard drug ethinyl estradiol (1 μg/kg) combination were t...

Objective(s): Several researchers have reported the relationship between infertility in male and varicocele for so many years but the implication of varicocele in female patients is remains elusive. Here, we aim to examine the effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality of rat ovary after the experimental creation of varicocele in female rats. Material...

Tnis(p-aminophenyl)carbonium pamoate (2 lots) was administered as drug-diet for an 18-month period to male and female albino rats (Holtzman source) . Both lots of compound were prepared from the chloride salt, one from an approximately 98.6 % pure sample, and the other from a highly purified and apparently homogenous sample. There was a marked increase in total tumor incidence in the treated fe...

conclusions the results of the present study revealed that the aloe vera aqueous extract had various effects on morphine withdrawal syndrome in morphine-dependent female rats . results the results of the present study showed that agitation, disparity, and floppy eyelids in group e were significantly higher than those of others groups; however, these symptoms in group c were significantly lower ...

Breast cancer is the most frequent type of invasive in women. However, chemotherapy affects all cells that grow and divide quickly body, including normal cells. On other hand, Graviola commonly used as a source food has wide range bioactive components. In this study, out 50 albino rats, breast was induced 40 rats using 7,12-dimethylbenanthracene (DMBA). These were subjected to treatment leaves ...

Background: Ageing is associated with the diminished function of various tissues in the body. The gonadal function decreases with the increase in age. Testes undergo atrophy resulting in shrinkage of seminiferous tubules due to reduced testosterone hormone level in elderly male. The process of spermatogenesis decreases in old age when compared to young adults. Today’s lifestyle makes an adult s...

Previous work in our laboratory showed that the recommended oral dose of buprenorphine (0.5 mg/kg) was not as effective as the standard therapeutic subcutaneous dose for postoperative analgesia in male Long-Evans (hooded) and Sprague-Dawley (albino) rats. The aim of the current study was to extend this analysis to female rats. We measured the pain threshold in adult female rats in diestrus or p...