Caraway, coriander and fennel are known hypoglycemic agents, which are used in folklori medicine for improving blood glucose level and preventing long term complications in diabetes mellitus. So, this study was designed to clarify their role on the histological and histochemical changes in kidney and islets of Langerhan in diabetic rats. 80 rats were divided into 5 groups. The first group was c...

In the present study Willbutrin (bupropion hydrochloride) was employed to induce mutagenic/ carcinogenic features in mice, i.e. undesirable cell division and DNA damage. The repair actions of fennel dry seeds and its extracted bioactive substance anethole supplied to Willbutrin-treatedmice in a dietary regime were investigated. Male Swiss albino mice (25-30gm) orally received Willbutrin dose (0...

foeniculum vulgare (fennel) has been widely used in traditional medicine for treatment of variousdiseases including pediatric colic. this study was designed to assess the antinociceptive effects of aqueousextract of f. vulgare on visceral pain and possible involvement of opioidergic, serotonergic, adrenergic andhistaminergic systems. the results of this study showed that aqueous extract of f. v...

This study is intended to prevent ochratoxin A (OTA) production by Aspergillus carbonarius S402 using essential oils (EOs) and total phenolic compounds extracted from plants and herbs. The EOs used in this study are the following: bay leaves, cumin, fenugreek, melissa, mint, and sage. As for the phenolic compounds, they were extracted from bay leaves, cumin, fenugreek, melissa, mint, sage, anis...

This double-blind, randomized, placebo-controlled trial evaluated the effectiveness of fennel seed oil emulsion in infantile colic. The results showed that the colic of 65% of the infants in the treatment group was eliminated compared with 23.7% in the control group; this difference was considered statistically significant. The study indicates that fennel seed oil emulsion is superior to placeb...

Introduction: Acetaminophen is a widely used analgesic and antipyretic drug. Although it is considered safe at therapeutic doses, at higher doses, might produces a centrilobular hepatic necrosis that can be fatal. In the present study, the effect of fennel seed on hepatotoxicity induced by acetaminophen was investigated. Correspondenc...

Infantile colic, defined as excessive crying in an otherwise healthy baby, is a distressing phenomenon, but there is little evidence to support the many treatments offered. Several small studies report some benefit from use of a hypoallergenic (protein hydrolysate) formula, maternal diet adjustment (focusing on a low-allergen diet), and reduced stimulation of the infant. While dicyclomine has b...