The initial dose selection is one of the important steps for any investigative new drug (IND) entering the first clinical study in humans. In this mini review, we will discuss the no observed adverse effect level (NOAEL) and the minimum anticipated biological effect level (MABEL) approaches for the estimation of the first in human (FIH) dose. Particular attention will be placed on the developme...

In its third observing run, the LIGO/Virgo collaboration has announced a potential neutron star-black hole (NSBH) merger candidate, GW190426_152155. Together with GW190814, these two events belong to class of binaries secondary mass less than $3 \, M_{\odot}$. While system in GW190426_152155 is consistent being star $1.5^{+0.8}_{-0.5} M_{\odot}$, that GW190814 $2.59^{+0.08}_{-0.09} M_{\odot}$ o...

The CLOS Metaobject Protocol (CLOS MOP) is a specification of how major building blocks of CLOS are implemented in terms of CLOS itself. This enables programmers to subclass meta-level classes and define meta-level state and behavior in an incremental fashion. The benefits of such a meta-level architecture for object systems in general and CLOS in particular are well documented. However, some p...

We discuss the possibility for users of CLOS to extend the mop:specializer metaobject class in the de facto standard Metaobject Protocol for Common Lisp, and how this possibility interacts with ANSI-standardized functionality. To motivate the discussion, we provide two simple examples: a specializer on a disjunction of classes and a simple pattern-matching specializer; we note the extent to whi...

In this paper, we consider the application of the the rmodynamic concepts to the study of connect ing networks such as those found in telephone systems as illustrated in Fig. 1. Basically, the problem is to obtain all possible connections between N inputs and N outputs given by the permutat ion group by means of a physical structure. This could, for example, be an N • N matrix. For telephone ap...