One of the most significant issues in pharmaceutical industries, prior to commercializationof a pharmaceutical preparation is the “preformulation” stage. However, far too attention hasbeen paid to verification of the software assisted statistical designs in preformulation studies.The main aim of this study was to report a step by step preformulation approach for a semisolidpreparation based on ...

Product design techniques that support mass customization include product platform design, computer-aided parametric design and modular design, among others. Unfortunately, no rigorous method has appeared until now to help designers combine these approaches systematically and maximize the quality and economic benefits of component commonality, particularly for very large number of product varia...

Background and Objectives: Oils used in frying should include special characteristics such as high oxidative stability, prolonged shelf life, low price, abundance and availability and desirable flavors. Nowadays, consumers are further interested in low saturated frying oils.  Recently, manufacturers focus on eliminating palm oil derivatives (as a major vegetable source of saturation) from fryin...

The goal of this study was to design and evaluate extended - release system of the hypnotic agent, Zolpidemtartrate usefulness for the treatment of insomnia. The half-life of this drug is about 1.9 - 3 hours that indicatingit a candidate for the extended release formulation. Our investigation relates to development of extendeddrug delivery system based on Hydroxy propyl methyl cellulose (HPMCK4...

Myocardial infarction, generally known as ‘heart attack’ occurs predominantly during the early morning hours and a cause of millions death worldwide. Hydrochlorothiazide is recommended drug for prevention heart disease, but commercial market lacks its long action (>4 h) formulation. The endeavor present research was to develop quality product profile hydrochlorothiazide modified release tablets...

an oral sustained-release floating tablet formulation of metformin hcl was designed and developed. effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and hpmc-peo polymer combination, respectively. tablet composition was optimized by response surface methodology (rsm). seventeen (17) trial formulations were analyzed according to box-behnken desi...