Polychlorinated biphenyls (PCB) have been suspected as possible contributors to increasing non-Hodgkin's lymphoma incidence during the latter half of the 20th century based on their toxicologic properties and provocative epidemiologic reports. We investigated PCBs and other organochlorines and risk of non-Hodgkin's lymphoma in a population-based case-control study in the United States. Congener...

Abstract. Furans are emitted to the atmosphere during biomass burning from pyrolysis of cellulose. They one major contributing volatile organic compound (VOC) classes OH and NO3 reactivity in plumes. The removal process furans at night is reaction with nitrate radical, NO3. Here, we report a series relative rate experiments 7300 L indoor simulation chamber Institut de Combustion Aérothermique R...

 Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (“dioxins”) is a term used to refer to a group of 210 compounds with similar chemical structures  Most of these compounds pose no health hazard at the levels commonly found but 17 of them are of more toxicological concern  The most toxic dioxin is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and most of the available data ...

A catalytic enantioselective reaction based on a copper(II) catalyst strictly containing chiral anionic ligands is described. In the present work, copper(II)-phosphate catalyst promotes the intramolecular heterocyclization of 2-(1-alkynyl)-2-alkene-1-ones and facilitates high levels of enantioselectivity in the subsequent nucleophile attack. Mechanistic studies suggest that formation of a coppe...

Disclosed herein is a stereoselective method for the synthesis of 2,3-furan fused carbocycles bearing adjacent quaternary and tertiary carbon stereocenters. The chemistry is based on an asymmetric addition of β-ketoesters to 2-(1-alkynyl)-2-alkene-1-ones catalysed by natural cinchona alkaloids followed by a silver-catalysed intramolecular cycloisomerisation. By exploiting the distinct catalysis...

A homogeneous catalyst system for the asymmetric cis-hydrogenation of 2,5-disubstituted furans leading to 2',3'-dideoxynucleoside analogues is described. Best enantioselectivities (ee values of up to 72%) were obtained with cationic rhodium complexes ligated by diphospholanes of the butiphane family. The selectivity of the hydrogenation was reversed by the addition of a base or a polar protic s...

The addition of lithium amides to cyclobutenediones provides access 2-oxo-but-3-enamides and tetrasubstituted furans via a new mode ring opening involving enone cleavage via O- C-lithium transfer.

Reaction of propargylic dithioacetals with BuLi followed by treatment with dialdehydes yields the corresponding allenyl carbinols which can be cyclized to give the 2,3,5-trisubstituted furans. The use of this strategy for the synthesis of a range of alternating benzene-furan oligoaryls is described.

A novel palladium-catalyzed cyclization of bromoacrylamides with isocyanides gives substituted 2,5-diimino-furans, which can be used as the precursor of maleamides. This synthesis likely proceeds, after isonitrile insertion into C–Pd(II) bond, through the coordination of the amide oxygen atom to the Pd(II) centre as a key step.

Palladium-catalyzed allylation reactions of 2-(chloromethyl)thiophenes, 2-(chloromethyl)furans, and N-protected 2-(chloromethyl)-1H-pyrroles with allyltributylstannane were described in this study. This type of allylation reaction regioselectively occurred on the heteroarene rings to produce allylated dearomatization products or allylated heteroarenes with satisfactory yields.