Biological RNAs that bind small molecules have been implicated in a variety of regulatory and catalytic processes. Inspired by these examples, we used in vitro selection to search a pool of genome-encoded RNA fragments for naturally occurring GTP aptamers. Several aptamer classes were identified, including one (the "G motif") with a G-quadruplex structure. Further analysis revealed that most RN...

Food and drinks can be contaminated with pollutants such as lead strontium, which poses a serious danger to human health. For this reason, number of effective sensors have been developed for the rapid highly selective detection contaminants. TBA, well-known aptamer selectively target thereby inhibit protein clinical interest α-thrombin, is receiving increasing attention sensing applications, pa...

We developed a method for aptamer identification without in vitro selection. We have previously obtained several aptamers, which may fold into the G-quadruplex (G4) structure, against target proteins; therefore, we hypothesized that the G4 structure would be an excellent scaffold for aptamers to recognize the target protein. Moreover, the G4-forming sequence contained in the promoter region of ...

Artan metabolik aktivite ve metastaz, kanser hücrelerinin ana en bilinen özellikleridir. Hücrelerin artan aktivitesi, G-dörtlü yapıların oluşumunda artışa neden olur. G-quadruplex'in çeşitli ligandlarla stabilizasyonu veya destabilizasyonu, hücre proliferasyonunda bozulmalara olabilir. Dolayısıyla, bu ikincil yapının destabilizasyonu önemli antikanser ilaç hedefleridir. Bu çalışmada, Bismarck k...